Introduction. About 50-66 % patients with cancer suffered from intensive pain when are given analgesics. Objectives. We investigated the effectiveness of intravenous infusion of non-selective purine receptors agonist adenosine triphosphate in cancer patients with moderate and severe pain who had being received non-selective inhibitor of cyclooxygenase plus weak opioid tramadol. Materials and methods. Sixty-seven patients in which pain sensations were localized in different regions were scheduled for the study. The intravenous infusion of adenosine triphosphate 3545 mcg kg(-1) min(-1) was performed within the period from 100 to 160 minutes. Pain severity was estimated by numeric verbal scale where “0” - no pain and “10” - maximal pain. Moreover, we studied prognostic significance of the original scale that was based on patient’s ability to pointed out precisely the pain sensation margins where “1” - patient can specify exactly the margins of pain sensations on the skin; “2” - patient can indicate approximately zone with pain sensation (periarticular tissue or bone or big muscle); and “3” - patient can determine large anatomical region only. Analysis of correlations was performed between scale value and the effectiveness of adenosine triphosphate infusion. Results. We revealed that 79 % (53 out of 67) patients have pointed out to pain relief after infusion with more than 20 % reduction of pain intensity (p = 0.0000001 - Wilcoxon signed rank test). As results, we obtained statistically correlation link (p = 0.02 - gamma-test and p = 0.02 - Kendall tau rank correlation coefficient) between the adenosine triphosphate infusion effectiveness and pain type with high precision of the pain sensation margins. Conclusions. Intravenous infusion of adenosine triphosphate has the high effectiveness for pain relief in cancer patients particularly when pain sensation margins high precisely detected to be.

The purpose of this study was to compare efficiency and safety of the prolonged Sub-Tenon block in comparison with IV 100 mg tramadol for long vitreoretinal surgery ander general anesthesia. 74 patients were undergoing microinvasive vitrectomy. For the prolonged Sub-Tenon block 1% solution of lidocaine at the speed of 2 ml/hour was used. The value of block of oculovisceral reflexes, HR and MAP, the need for muscle relaxants, time of awakening and time of removal of a laryngeal mask, postoperative pain and analgesia requirements, and postoperative nausea and vomiting were recorded. In prolonged Sub-Tenon block group there was more effective blocking of oculocardiac and oculovasomotor reflexes, a smaller average dose of muscle relaxants, shorter awakening time and removal of a laryngeal mask, and also lower pain syndrome in the first 24 hours after surgery. Postoperative nausea and vomiting also was in Sub-Tenon block group considerably less frequent than in tramadol group. Use of the prolonged Sub-Tenon block with the general anesthesia is an effective and safe technique for vitreoretinal surgery.

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Introduction. In different countries, the number, training, field of activity and social status of anesthesiologists vary greatly, as well as the exact professional scope of the specialty. To develop work plans and develop the professional community, the Federation of Anesthesiologists and Resuscitators of Russia conducted a questionnaire survey on the actual situation of the professional activities of anesthesiologists and resuscitators. Objectives. To characterize the professional component of the sociological portrait of the Russian doctor-anesthesiologist-resuscitator based on the results of a mass survey. Materials and methods. The questionnaire survey (paper forms and online questionnaires) was carried out in 83 regions of Russia; 3108 anesthesiologists and resuscitators participated in the study. Results. The main type of professional activity is: practical work - 96.3 %, teaching - 2.8 %, scientific activity - 0.9 %. It was found that 60 % of the survey participants devote all their working time to practical work, 71.3 % and 74 % of the respondents are not at all engaged in teaching and scientific work, respectively. The positions of respondents, their job responsibilities, categories of organizations, length of service and qualification categories of doctors, self-assessment of the level of professional skill, and ways of improving their qualifications were analyzed. Satisfaction with various aspects of their work, reasons for dissatisfaction with their work, issues of social protection, the desire to change jobs or the nature of work were also assessed. Conclusions. The sample of the survey is skewed, uniting specialists with a high status in the profession and young active colleagues. The need for continuing medical education is not yet sufficiently met. Information about professional vacancies on the website of the Federation of Anesthesiologists and Resuscitators may be a popular information resource.