Previous studies have shown an increased incidence of erectile dysfunction (ED) among patients diagnosed with cardiovascular disease (CVD). Both conditions, which may be a consequence of underlying endothelial dysfunction, share many risk factors such as hypertension, dyslipidemia, diabetes, depression, obesity, and cigarette smoking. Because vascular disturbance of the penile endothelium leads to ED, the possibility arises that ED may be an early indicator for systemic endothelial dysfunction and subsequent CVD. Recognizing ED as a disease marker for CVD may help to identify individuals at risk for having a premature cardiovascular event.

OBJECTIVES:Underactive bladder (UAB) and detrusor underactivity (DU) are receiving increasing clinical and research attention. Although lacking a formalized definition, UAB is described as a symptom complex, while DU is a standardized statement of urodynamic function. Both terms nominally suggest impaired detrusor contractility leading to disordered emptying. We sought to evaluate the relationship between UAB, DU and detrusor contractility. METHODS:A chart review of 256 urodynamic records from clinical practice was conducted. Data about symptoms and urodynamic performance were extracted and analyzed, comparing measures of sensory and motor function among groups based on symptoms and urodynamic observations. RESULTS:One hundred and ninety eight complete urodynamic studies met ad hoc defined criteria for inclusion. UAB is specific (0.90) for, but not sensitive (0.22) to, DU. Increased post-void residual volume is common to both UAB and DU, but neither is associated with impaired contractility as measured by Watts factor. Patients with UAB and DU demonstrate higher sensation volume thresholds than do those without these symptoms or observations. CONCLUSIONS:The symptom complex of UAB is not a reliable predictor of the urodynamic observation of DU, and neither condition is associated with a diminished Watts factor. Our results suggest that UAB and DU are typically disorders of volume hyposensitivity rather than of impaired contractility, and may differ in their relationship to bladder perceptions. Thus, these terms should not be used interchangeably.

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