Erectile Dysfunction

Shin, David S.; Pregenzer, G; Gardin, Julius M.

doi:10.1097/crd.0b013e3181fb7eb8

Cited by 80 publications

(19 citation statements)

References 68 publications

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“…Furthermore, much evidence suggests that vascular abnormalities such as endothelial dysfunction and atherosclerosis play a critical role in both conditions (3, 5). Importantly, the concept that ED is a prior indicator of CVD is growing stronger (6)*.…”

Section: A-introductionmentioning

confidence: 99%

New insights into hypertension-associated erectile dysfunction

Nunes

Labazi

Webb³

2012

Current Opinion in Nephrology and Hypertension

110

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Purpose of review Erectile dysfunction (ED) is recognized as a quality of life disorder that needs to be treated. Currently, it is estimated to affect as many as 30 million American men. Thirty percent of hypertensive patients complain of ED. The understanding of common mechanisms involved in the etiology of ED associated with hypertension, and the investigation of antihypertensive drugs that impact ED, will provide important tools toward indentifying new therapeutic targets that will improve the quality of life for patients in these conditions. Recent findings Hypertension and ED are closely intertwined diseases which have endothelium dysfunction as a common base. During hypertension and/or ED, disturbance of endothelium derived factors can lead to an increase in vascular smooth muscle (VSM) contraction. Hypertension can also lead to ED as a consequence of high blood pressure (BP) or due to antihypertensive treatment. However, growing evidence suggests ED as an early sign for hypertension. Also, some PDE-5 inhibitors used to treat ED can improve BP, but the link between these conditions has not been totally understood. Summary This review will discuss the interplay between hypertension and ED, exploring newest insights regarding hypertension-associated ED, as well as the effect of antihypertensive drugs in ED patients.

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Section: A-introductionmentioning

confidence: 99%

New insights into hypertension-associated erectile dysfunction

Nunes

Labazi

Webb³

2012

Current Opinion in Nephrology and Hypertension

110

View full text Add to dashboard Cite

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“…Penile erection occurs when there is a relaxation of the smooth muscle cells in cavernosal arterioles and surrounding sinuses, resulting in increased blood flow into the penis associated with a pressure-dependent veno-occlusive mechanism within the sinuses controlling the blood outflow [ 1 , 2 ]. The major mechanism responsible for ED is an increase in the tone and/or contractility of the smooth muscle within the corpus cavernosum and penile arteries [ 3 ], which is mostly due to diminished production and function of nitric oxide (NO) and other vasoprotective factors, which is compounded by the exaggerated production of reactive oxygen species (ROS) and vasoconstrictors [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment with CB₂Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice

Fraga‐Silva

Costa‐Fraga

Montecucco

et al. 2013

Clinical and Developmental Immunology

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Hypercholesterolemia is one of the most important risk factors for erectile dysfunction, mostly due to the impairment of oxidative stress and endothelial function in the penis. The cannabinoid system might regulate peripheral mechanisms of sexual function; however, its role is still poorly understood. We investigated the effects of CB2 activation on oxidative stress and fibrosis within the corpus cavernosum of hypercholesterolemic mice. Apolipoprotein-E-knockout mice were fed with a western-type diet for 11 weeks and treated with JWH-133 (selective CB2 agonist) or vehicle during the last 3 weeks. CB2 receptor expression, total collagen content, and reactive oxygen species (ROS) production within the penis were assessed. In vitro corpus cavernosum strips preparation was performed to evaluate the nitric oxide (NO) bioavailability. CB2 protein expression was shown in cavernosal endothelial and smooth muscle cells of wild type and hypercholesterolemic mice. Treatment with JWH-133 reduced ROS production and NADPH-oxidase expression in hypercholesterolemic mice penis. Furthermore, JWH-133 increased endothelial NO synthase expression in the corpus cavernosum and augmented NO bioavailability. The decrease in oxidative stress levels was accompanied with a reduction in corpus cavernosum collagen content. In summary, CB2 activation decreased histological features, which were associated with erectile dysfunction in hypercholesterolemic mice.

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“…First, both choroid and penis have a rich vasculature and impaired microcirculation has been disclosed in the choroids of patients with neovascular AMD and in the penises of men with ED [22–24]. Second, some recent studies have demonstrated that disorders with endothelial dysfunction are associated with ED [25].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Neovascular Age-Related Macular Degeneration and Erectile Dysfunction

Çakmak

Kocatürk

Dündar

et al. 2013

Journal of Ophthalmology

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Purpose. To evaluate association between erectile dysfunction (ED) and neovascular age-related macular degeneration (AMD). Methods. 195 men enrolled in this cross-sectional study. 90 of them had neovascular AMD and 105 of them were healthy volunteers. The International Index of Erectile Function (IIEF) questionnaire's erectile function (EF) domain was used to assess ED. The patients in the study and control groups were statistically compared according to visual acuity, EF score, and body mass index. Results. The mean ages were 62 (54.5–73) and 60 (54–68), in the neovascular AMD and control groups, respectively. The total EF scores were 9 (6–16) in neovascular AMD and 18 (9.5–27) in control group. The results of IIEF questionnaire on neovascular AMD patients revealed that 85 men (94.4%) had some degree of ED, whereas 68 men (64.8%) had some degree of ED on control group. Patients with neovascular AMD had a significantly higher incidence of ED than control patients (P < 0.01). There was a significant association between ED and neovascular AMD (P < 0.01). Conclusions. Our results suggested that neovascular AMD has a high association with ED.

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Erectile Dysfunction

Cited by 80 publications

References 68 publications

New insights into hypertension-associated erectile dysfunction

New insights into hypertension-associated erectile dysfunction

Treatment with CB₂Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice

The Relationship between Neovascular Age-Related Macular Degeneration and Erectile Dysfunction

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Erectile Dysfunction

Cited by 80 publications

References 68 publications

New insights into hypertension-associated erectile dysfunction

New insights into hypertension-associated erectile dysfunction

Treatment with CB2Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice

The Relationship between Neovascular Age-Related Macular Degeneration and Erectile Dysfunction

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Treatment with CB₂Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice