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Previous analyses greatly underestimated the cost-effectiveness of SD-FFP. Inclusion of non-infectious complications suggests that SD-FFP is cost-effective in patients < or = 48 years of age and in older patients with good clinical prognosis, which may justify the wider use of this technology.

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SYNOPSIS In a patient with generalized prostatic carcinoma and hypofibrinogenaemia heparin infusion on four occasions abolished systemic fibrinolysis as determined by euglobulin clot lysis time, bovine fibrin plate assay, thromboelastography, and immunoelectrophoretic demonstration of fibrinogen split products.The pathogenesis of hypofibrinogenaemia in cases of prostatic carcinoma and the possibility of a direct heparin effect on fibrinolysis are discussed. Despite the lack of histological evidence for intravascular coagulation, the findings are considered additional evidence for the view that fibrinolysis in this syndrome may be secondary to intravascular coagulation.

The dimorphic blood picture in sideroblastic anemia suggests the coexistence of at least two types of erythrocyte, the populations with the smaller RBCs being responsible for the crucial abnormality, namely the impairment of iron incorporation into protoporphyrin. In a patient with sideroblastic anemia who subsequently developed acute myelocytic leukemia, we found a light and a heavy cell population to be morphologically different, the lighter cells showing a smaller MCV and lower MCH, a higher reticulocyte count, fluorocyte count and protoporphyrin content. Radioiron uptake and 51Cr survival were 3.5% and 8.2 days for the lighter fraction, 37% and 20 days for the heavier fraction. Thus, the impairment of iron incorporation, the high erythrocyte protoporphyrin content, and the reduced survival of red cells in this patient with sideroblastic anemia appeared to be largely confined to the red cell population with the smaller RBCs.