Molecular allergy diagnosis allows to identify sensitization to a large range of respiratory allergens, which is important in the diagnosis of allergic asthma. Moreover, based on the reactive IgE profile detected at an early age, it is possible to predict the development of allergic respiratory diseases even at the preclinical stage. The goal of the pilot project was to create a children's passport sensitization using a multiplex panel to be able to identify groups at risk for the development of asthma in children of early school age. Materials and methods. Parents of 33 students studying in the second grade of the Tashkent gymnasium were questioned using the ISAAC questionnaire for the clinical manifestations of respiratory diseases in their children. Their children’s sera were tested for the presence of IgE to various allergenic molecules using the MeDALL research method. Results. 30% of children were sensitized to at least one allergen, and 30% of them were born by Caesarean section. and 30% of them were born by Caesarean section. In total, 68 of the 176 allergenic molecules located on the MeDALL microchip were recognized. 80% of sensitized children had a genuine polysensitization to 3 or more major allergens. In 18% of children, IgE to household molecules of the risk of developing asthma, such as Alt a 1, Bla g 1, Bla g 2, Can f 1, Fel d 1, were detected. Conclusions. In general, clinical manifestations in the form of wheezing and obstruction were detected in 60% of sensitized children, but only 40% of these children were under the supervision of an allergist or received symptomatic treatment. In 20% of already sensitized children, clinical symptoms were absent. Molecular testing of the profile of IgE sensitization and the creation of an allergic passport allows us to identify a group of children at risk for developing asthma. This information can be used to assign therapy and secondary prevention of asthma in the early school years.

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Aim:The aim of the study was to study the effect of correction of endothelial dysfunction on the clinical and immunological parameters of patients with bronchial asthma with a long history of the disease. Materials and methods:We examined 86 patients with mild and moderate-onset persistent asthma at the age of 18-55 years (38.5±4.2 years), with a duration of disease more than 12 years (on average 16+4.5years). Two groups were formed by random sampling. Patients of the main group (n=44), in addition to the standard basic therapy (GINA, 2007) received a nitric oxide donor -L-arginine. The comparison group (n=42) received only basic therapy. As a control, 15 practically healthy persons were examined. The condition of the endothelial system was assessed before and after the ten-day course, and also after 1 month of treatment according to the following indices. In the dynamics of treatment, the immunological parameters in the blood and in the condensate of exhaled air were also evaluated. Conclusion:In patients with a long course of persistent asthma of moderate severity with the use of L-arginine in addition to basic therapy, which contributes to an earlier and reliable improvement of the immunological parameters studied. Citation: Alyavi AL, Bazarov SA, Sadykova GA, et al. Effect of correction of endothelial dysfunction on clinical and immunological parameters in patients with bronchial asthma. Int J Radiol Radiat Ther. 2018;5(2):76-78.