A series of bisdiguanides has been prepared either by condensing one mol. of a biscyanoguanidine with two mols. of an amine hydrochloride, or by the converse interaction of two mols. of an N-arylcyanoguanidine with one of a diamine salt. One of the products, 1 : 6-di-(N5-p-chlorophenyl-N1-diguanido)hexane (chlorohexidine B.P.C.), has found practical use as an antibacterial agent.

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The inhibitory effect, upon Gram-positive bacteria, of diethyl stilboestrol and hexoestrol has been confirmed but was not reversed by lecithin or cholesterol. Dienoestrol is also inhibitory, but its dibenzoate and dipropionate esters bre not.

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The preparation is described of a series of sulphanilamide derivatives of pyrimidine by allowing p-nitro-, p-amino-or p-acetaddo-benzenesulphonylguanidine t o react with /I-diketones or b-ketocarboxylic esters.