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Acid hydrolysis of cordycepin yields adenine and cordycepose. Cordycepose (VI) is shown to be a 3-deoxypentose with a branched carbon chain, and cordycepin is shown to be 9-cordyceposidoadenine (IX) .PART I * described the isolation of a crystalline metabolic product, cordycepin, from culture fluids of Cordyceps militaris (Linn.) Link. Analyses of cordycepin and its derivatives indicated a molecular formula C,,H,,O,N, for the former, and preliminary examination revealed that the molecule contains three active hydrogen atoms but no methoxyl, C-methyl or N-methyl groupings.The first indication of the nature of cordycepin was obtained from a consideration of its ultra-violet absorption spectrum which exhibits a well-defined maximum a t 2600 A . (E fi 15,000) in neutral, acid, or alkaline solution. This absorption spectrum is very similar to those of adenine, 9-methyladenine, and adenosine (9-D-ribofuranosidoadenine) (Gulland and Holiday, J., 1936, 768 ; Table I) but substantially different from that of 7-methyladenine.

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