An endo-perio lesion has been one of the prevalent issues affiliated with the tooth. The cutaneous involvement of pulpal and inflammatory periodontal pathology can perplex the diagnosis and treatment planning. The present case report shows the synergic effect of endodontic, periodontal, and esthetic therapy. The treatment includes root canal therapy and open debridement followed by the placement of "sticky bone" graft and guided tissue regeneration membrane over the osseous defect site. After 6 months, a coronally advanced tunneling procedure with connective tissue graft placement was performed to improve esthetics. The patient was followed up for 1 year. Clinically, there was a reduction in probing pocket depth, increase in attached gingiva, and improvement in gingival biotype. Radiographically, there was a resolution of periapical radiolucency and a significant amount of bone fill was observed. Hence, the coactive effect of various regenerative materials with root canal sealing had significantly improved both clinical and radiographic features of the endo-perio lesion.