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Automatically titrated O flows (FreeO) was compared with constant O flow on exercise capacity, O saturation and risk of hyperoxia-related hypercapnia in patients with severe COPD with baseline hypercapnia and long-term oxygen therapy (LTOT). Twelve patients were enrolled in a randomised double-blind cross-over study to perform exercise with either FreeO or constant flow. Endurance time (primary outcome) and SpO were both significantly improved with FreeOcompared with constant flow (p<0.04), although pCO was similar in both conditions. Automated titration of O significantly and clinically improved endurance walking time in patients with severe COPD receiving LTOT, without worsening of pCO TRIAL REGISTRATION NUMBER: Results , NCT01575327.

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