In 30 male patients several EEG examinations could be carried out during delirium tremens (d.t.) or shortly thereafter. Most of the patients showed a normal EEG or changes which can be explained with regard to sedation through medication. 1 patient showed generalized paroxysmal spike wave bursts. On account of experimental results, we may assume that a transitory cerebral excitibality change occurs in d.t. This pathophysiological basis explains the normal EEGs and paroxysmal bursts during d.t. 4 cases showed passages of pronounced diffuse slow activity during d.t. partly accompanied by rhythmic bilateral slow waves. These changes point to a complication of d.t. that occurs because of another disease which results in cerebral functional disturbances as in other organic psychoses.

We assess the effect of an intravenous glucose load on production of glucose in lactating dairy cows. Isotope dilution techniques were utilized to measure transfer rate of plasma glucose (with tritiated glucose) and gluconeogenesis (with carbon-14 labeled propionate or carbon dioxide). A glucose load equivalent to the cow's normal transfer rate decreased endogenous glucose output two-thirds and decreased gluconeogenesis by half. Glucose concentration and transfer rate were higher within 2 h after glucose load started while carbon-14 transfer to plasma glucose became increasingly depressed and persisted for at least 1 h after loading terminated. Reduced plasma glucose synthesis from propionate during loading was associated with increased transfer of propionate carbon to plasma phospholipids, triglycerides, and cholesterol esters, and with increased plasma insulin concentration. It appears that glucogenic precursors are utilized for greater synthesis of lipid (and presumably glycogen) and that loading leads to metabolic changes causing net reduction in gluconeogenic capacity. These changes could have important implications for use of intravenous glucose in treating hypoglycemic metabolic conditions.

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