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The development of bioconjugates is of pivotal importance in medicinal chemistry due to their potential applications as therapeutic agents to improve the targeting of specific diseases, decrease toxicity, or control drug release. In this work we achieved the synthesis and characterization of three novel opioid peptides fluorescently labeled, analogues of cyclic biphalin derivatives, namely 1D, 1C, and 2C. Among them, compound 1D, containing a dansyl-maleimide motif, exhibited an excellent binding affinity and functional potency for the δ-opioid receptor (DOR). 1D also demonstrated a strong fluorescence emission spectrum ranging from 300 to 700 nm. These features could be highly desirable for medical and biological applications needed for targeting the DOR, including in vivo imaging, and as a lead for the design of fluorescent probes.

The relevance of the article is to study the effectiveness of group work in teaching written speech in English to high school students. The authors consider how group work can help improve English writing skills, including essays. The main purpose of the study is to determine the effectiveness of group work in teaching written language in English. The objectives of the study are to describe the results of group work to improve written skills, compare the results of written skills compared with students who use traditional (based on the curriculum and textbooks) methods of teaching English written. The influence of the method of group work during the teaching of written speech on the attitude and perception of students of this type of foreign language speech was also established. The basis of group work in teaching written speech is based on the idea of well-known scholars about the need to collaborate with others, bringing ideas for quality learning and growth. Social interaction, as the basis of cognitive development in sociocultural theory, is the basis of this article. Our main belief is that the cognitive growth of each child is the result of social interaction. This theory plays an important role in influencing the practice of teaching writing fatigue in the classroom. Some scholars have stated that their research has shown that by activating written learning through group work, students can benefit from collaboration, which is an important factor in improving the various components of writing, including grammatical and structural accuracy. The results of the study showed that group work contributes to the generation of ideas and the development of changes in attitudes to written speech in English. The results showed that group work is a strategic tool that helps students effectively master writing skills in English lessons and is consistent with the findings of other scholars mentioned in the literature review.