Colorectal cancer (CRC) is the third most prevalent malignancy worldwide, and one of the most common causes of cancer-related deaths. The main tumor-related prognostic factor after surgical resection is initial pathologic staging and lymph node involvement is a major determinant of disease recurrence. The addition of adjuvant chemotherapy in stage III patients undergoing surgical resection decreases tumor recurrence by around 40% to 50%. However, a significant proportion of patients still experience systemic recurrence. In CRC, 18F-FDGfluorodeoxyglucose (18F-FDG-PET-CT) plays a key role in the detection of recurrent disease in post-therapy assessment of residual masses and patient staging before surgical resection of liver metastases. We report the case of a 52-year-old patient with stage III colorectal cancer, who underwent surgical resection and completed adjuvant chemotherapy, followed by imaging techniques (Fluorine-18-FDG PET-CT and magnetic resonance) mimicking early peritoneal and ovarian recurrence.

Introduction: Sida santaremnensis H. Monteiro (Malvaceae) is a plant popularly known as "vassourinha" or "guanxuma" that has been described as vasorelaxant, antiulcerogenic, antinociceptive and antiedematogenic. Objective: To contribute with the phytochemical and pharmacological profile of Sida santaremnensis through the isolation, purification and determination of chemical constituents of this plant, as well as through the evaluation of the anti-inflammatory and antitumor activity and leishmanicidal effect of the isolated constituent in a greater amount. Methods: The isolation of substances from the plant herein studied was performed with column chromatographic and analytical thin-layer methods and structural determination made by spectroscopic methods, such as Nuclear Magnetic Resonance, Hydrogen and Carbon 13, and comparisons with data from the literature. To assess pharmacological activities, cell viability tests, determination of nitric oxide levels, leishmanicidal activity, among others, were performed. Results: Two flavonoids from S. santaremnensis were obtained, kaempferol (S-1) and kaepferol 3-O-β-D-glycosyl-6’’-α-L-rhamnoside (S-2), the latter in a greater amount. The evaluation of the antitumor activity of the glycosylated flavonoid demonstrated that it does not present hemolytic activity against the human promyelocytic leukemia cell line (HL-60), and that it presented weak leishmanicidal activity. The immunopharmacological evaluation of kaempferol 3-O-β-D-glucosyl-6’’-α-L-rhamnoside revealed that it presents a possible anti-inflammatory action related to the inhibition of the production of nitrite by LPS-stimulated macrophages. Conclusion: These data demonstrate that kaempferol 3-O-β-D-glucosyl-6’’-α-L-rhamnoside has low toxicity, in addition to antileishmania, anti-inflammatory and immunomodulatory properties, which makes it a therapeutic potential for infectious and inflammatory diseases mediated by macrophages.