The present study was carried out to evaluate the antioxidant activity of and the content of bioactive compounds in camu-camu fruits harvested at different maturation stages and stored. The fruits were harvested in the municipality of Cantá, Roraima State, Brazil. The experimental design was completely randomized, with three replications, in a factorial arrangement consisting of three different maturation stages (immature, semi-mature and mature) and eight days of storage (3 x 8). The fruits were analysed every day regarding total vitamin C, carotenoids, anthocyanins, flavonoids, total phenolic compounds, and antioxidant activity (FRAP and DPPH). According to the results obtained, the interaction of maturation stages x eight days of storage had a significant effect according to the F test at 5% probability. The highest antioxidant activity (FRAP) was observed in the fruits harvested in the semi-mature stage, providing a longer shelf life. The carotenoid pigment, flavonoid, anthocyanin, and vitamin C contents were higher in the fruits harvested in the mature stage, and this stage was the most suitable for obtaining these functional biocompounds. Additionally, in mature fruits, the highest mean content of total phenolics and antioxidant activity (DPPH) were observed during storage. It was concluded that the mature stage is the most recommended for the extraction of pigments and antioxidant biocompounds from camu-camu fruits.

The objective of this work was to formulate and to characterize chemically and physically different formulations of camu-camu jellies, with or without mixture of other fruits. Their sensory acceptance was evaluated by identifying the formulations with greater acceptability while maintaining their nutraceutical potential. The formulations were: camu-camu jelly, camu-camu jelly with jabuticaba, camu-camu jelly with guava, camu-camu jelly with acerola, camu-camu jelly with passion fruit and camu-camu jelly with papaya. Untrained tasters were used to assess consumer acceptability. In a second scale the purchase intention was evaluated. The following variables were also analyzed: pH, soluble solids, titratable acidity, ratio (SS/TA), ascorbic acid, total anthocyanins and flavonoids, phenolic compounds and antioxidant activity by the DPPH and FRAP methods. The results showed that camu-camu jelly without mixtures was not well accepted in the sensory test when compared to the others. The greatest preference was for mixed jams of camu-camu with guava and jabuticaba, in which they obtained greater acceptance and purchase intention. Jellies with higher levels of bioactive compounds and antioxitant activity obtained low acceptance and purchase intention, perhaps due to their high astringency.

The Amazon region is an important center of origin and diversification of fruit species, which produce fruits with unique characteristics in flavor, aroma, and high pharmacological, food and nutraceutical capacity. The camu-camu (Myrciaria dubia (Kunth) Mc Vaugh), also known as caçari, guinea fowl, or sarão is a species belonging to the Myrtaceae family, native to Amazonian floodplains and lakes (Roberto Nobuyuki Maeda et al., 2007). Today camu-camu is seen as an important alternative for local social and economic development. This is due to its ability to grow and produce areas of low agronomic value that would generally be unsuitable for crops of other species (Azevêdo et al., 2015). In Peru, it is considered as one of the drivers of economic growth in the country, being considered a good source of income for its producers (Correa Meléndez et al., 2013). Due to growing demand for healthy products and foods, the camu-camu stands out for being a nutraceutical and functional

Primary sarcomas of the breast originate from connective tissue and are responsible for less than 1% of all breast malignancies with an incidence of 5 cases per million in the United States. Primary breast angiosarcoma originates in the parenchyma and can secondarily compromise the skin and pectoral muscles in advanced cases. Sarcoma is present more in women between the ages of 14 and 82, mainly in the third and fourth decades of life. At diagnosis, as in other sarcomas, the size is bigger than 5 cm, with a direct correlation with prognosis; because of few data in literature due to its incidence and frequent error and the inespecific clinical and radiological signs, we report a case of breast angiosarcoma in a male patient from the Hospital Santo Antônio/Obras Sociais Irmã Dulce, Salvador, BA. It is the case of a 42-year-old man with a nodule in the upper medial quadrant of the right breast, measuring 2 cm. The mammogram and ultrasound showed a 1.4-cm regular nodule in the upper medial quadrant, BI-RADS 4. The patient underwent a core biopsy with a pathology reporting a chronic inflammatory process and a nonmalignant neoplasia; immunohistochemical positive for CD 68 and LCA and negative for cytokeratin 34beta12, P63, and cytokeratin AE1/AE3. Then, the nodule was excised and the pathology result showed a fusiform cell neoplasia with a positive posterior margin confirmed by immunohistochemical that neoplastic cells were positive for CD34 and CD31, negative for cytokeratin AE1/AE3, and inconclusive to smooth muscle actin with KI-67 <10%, leading to the diagnosis of angiosarcoma. After that, the margins re-excision the pathological staging (American Joint Committee on Cancer) ypT0. No evidence was found for metastases in other sites. The patient is now waiting for radiotherapy for local control benefits. There were 16 fractions in the right breast and a multidisciplinary follow-up. The discussion showed a rare case in the literature in agreement with the 170 cases reported, with a great impact when seen in men since the case reported prevalence in women. In relation to diagnosis, it becomes a challenge, especially in low-grade malignant tumors with multiple tissue pieces and needed the best pathology analysis, which could delay treatment. The inespecific alterations in imaging examinations as well as at tests, such as the presence of fatty tissue in a mammogram, would include hemangiomas and angiolipomas as differential diagnosis contributing to delay in the diagnosis. As treating large tumor resection due to aggressive behavior is recommended, it is a therapeutic option if associated with radiotherapy reducing risk by 20–50%. That was the treatment adopted for the patient described above. This study, besides contributing to the literature on angiosarcoma incidence, also affects the possible presentation in male patients, elevating the diagnostic hypothesis of nodule in the cases of early adequate treatment.

No Brasil, o cupuaçu possui uma cadeia produtiva muito importante, principalmente para pequenos produtores rurais. É popular no país todo, sendo mais produzido em sua região de origem, na região Amazônica, e no nordeste brasileiro. É uma fruta com diversas aptidões. As mais populares são o uso das cascas e das sementes para compostagem e a polpa vendida principalmente como polpa congelada para sucos, cremes e sorvetes. A manteiga, feita a partir do óleo das sementes de cupuaçu, tem se tornado cada vez mais popular, sendo utilizado em pequenas e grandes indústrias de cosméticos devido a presença de ácidos graxos e benefícios interessantes para saúde da pele e cabelo, ótimo emoliente e alto índice de saponificação. Porém a extração do óleo ou manteiga não é popular ou incentivada entre os produtores da fruta ou da polpa, que geralmente descartam as sementes, em grande quantidade, desperdiçando oportunidades de renda. Com o intuito de organizar informações sobre o assunto, foi elaborada uma revisão de literatura, que teve como objetivo buscar artigos que exemplificassem e descrevessem, por meio de informações básicas, as principais informações sobre o óleo de cupuaçu e os métodos de extração mais utilizados, principalmente aqueles acessíveis a agroindústria familiar. Para a coleta de dados foram utilizadas as bases de dados das plataformas Scielo, Google Acadêmico e a Base de Dados da Embrapa (Empresa Brasileira de Pesquisa Agropecuária). Foram encontrados métodos de extração por meio de prensas ou solventes e informações que podem contribuir para a valorização e popularização do óleo de cupuaçu, assim como incentivar a extração agroindustrial do mesmo.