Preeclampsia is still one of the leading causes of maternal and fetal morbidity and mortality. It is associated with insulin resistance & increase in Free Fatty Acids and plasma Triglycerides well above that seen in normal pregnancy. The pattern of dyslipidemia seen in preeclampsia may predispose these women to future cardiovascular diseases. The aim of this study was to compare the alteration in lipid profile and also the calculated risk ratios of women who developed Preeclampsia with normotensive pregnant women. This cross sectional study was carried out in Mahatma Gandhi Memorial Government Hospital, Trichy, Tamilnadu.100 women with preeclampsia and 100 normotensive pregnant women as controls were included in the study after obtaining their informed consent. The diagnosis of Preeclampsia was done as per the norms of American college of Obstetrics and Gynecologists. Fasting blood samples were collected. Serum glucose, cholesterol, triglycerides, and HDL-C were estimated by standard methods using standard kits. LDL-C was calculated by Friedwald's equation. All the results were analyzed statistically using ANOVA technique. There was significant elevation of total cholesterol, triglycerides, LDL, VLDL and risk ratios TC/HDL and TGL/HDL and decrease in HDL in Preeclamptic group compared to normotensives (p<0.0001). The dyslipidemic pattern of elevated TGL and reduced HDL which was also reflected in highly elevated TGL/HDL seen in preeclamptic patients is definitely atherogenic and may lead to future maternal cardiovascular disease. Hence simple measurement of lipid profile at 20 weeks of gestation can help in preventing the complications of PIH and future cardio vascular risk of the mother. Further studies in larger population in various ethnic groups are required to predict maternal future cardiovascular risk and its prevention by lifestyle modifications and therapy.

BACKGROUND: The appearance of TPO-Abs precedes thyroid dysfunction and increases in autoimmune diseases like type1diabetes.Thyroid peroxidase (TPO) antibodies are one of the major secondary antibodies associated with autoimmune thyroid disease and can be used as diagnostic marker. The prevalence of thyroid auto antibodies is increased when patients have non-thyroid autoimmune diseases such as type 1 diabetes and pernicious anemia. Thyroid dysfunction is common among diabetic patients and can produce metabolic disturbances. Therefore, regularly screening diabetic patients allows early treatment. OBJECTIVE: The objective of our study is to measure TPO-Abs in young Type-1Diabeticindividuals and to find Thyroid abnormalities in TPO-Abs positive individuals. MATERIALS AND METHODS: This was a cross-sectional study conducted at a rural clinic in Tiruchirappalli, Tamil Nadu. 60 persons in the age group of 10 to 35 years were selected for this study. Fasting blood samples were collected from the study population and glucose, lipid profile, thyroid profile and TPO-Ab were estimated using standard kits by standard methods. RESULTS:16 persons showed high levels of anti TPO-Abs(> 40 IU).In the anti TPO-Ab Positive group, all values were statistically significant according to the Pearson R formula P < 0.001. There was significant correlation between age and anti TPO-Ab level, between weight, BMI and TPO Positive and Negative levels, as per the T-Test P <0.001.56.30% of anti TPO-Ab Positive subjects had high TSH. CONCLUSION: Our results indicate that thyroid dysfunctionis common in Type-1 diabetes but more in anti TPO-Ab positive subjects. Hence all Type-1 diabetic individuals should undergo annual screening of serum anti TPO-Ab and TSH measurement in anti TPO-Ab positive individuals.

Chronic kidney disease (CKD) is a reduced glomerular filtration rate and/or increased urinary albumin excretion. The worldwide prevalence of chronic kidney disease (CKD) ranges from 8 to 16 %, and the prevalence of CKD is rising. The aim: To study the association between CKD stages, proteinuria, and lipoprotein (a) levels among the study participants. Materials and methods: This study was an institution-based observational case-control study involving CKD patients as study group and healthy volunteers as control one. Blood samples were tested for urea, serum creatinine, uric acid levels, triglycerides, total cholesterol, HDL cholesterol, VLDL cholesterol and serum lipoprotein. Statistical analysis was done with SPSS version 20.0. Result: In our study, the most common age group affected among cases was 41 to 50 years (5th decade), and there was a male preponderance in CKD. CKD patients had a higher mean protein creatinine ratio than controls, and this difference was statistically significant. In addition, CKD patients had significantly higher total cholesterol, triglyceride levels and lower HDL cholesterol levels than controls. Also, they had significantly elevated serum lipoprotein (a) levels than controls. Conclusion: Based on our study findings, we can conclude that because of the potential role of lipoprotein (a) in the development of cardiovascular disease, it is imperative to include an estimation of lipoprotein (a) levels in all CKD patients, especially in later stages to give a targeted therapy for dyslipidemia among CKD patients