To reduce the end-to-end average delay of algorithm in wireless network, this paper proposes the real-time routing algorithm in spectrum network. It is analyzed that the dynamic changes of the radio network model and routing algorithm in spectrum network. Through using Markov state transition and adjusting the router with scaling factor, the high-quality resources in the network can be obtained and fully utilized, and then these can reduce the transmission time latency rate and timely adjust the route. After that the tendency of spectrum network and specific real-time algorithm are given. Finally, by using the network simulation NS-2, simulation experiments are used to estimate the performance test. Experimental results show that compared with the traditional algorithm, the proposed algorithm can obtain a lower end-to-end average delay and improves network throughput and the steady and reliability of the link connection.