Coal is not only an important energy source in China but also a major source of air pollution. Because of this, China's national sulfur dioxide (SO(2)) emissions have been the highest in the world for many years, and since the 1990s, the territory of China's south and southwest has become the third largest acid-rain-prone region in the world. In order to control SO(2) emissions, the Chinese government has formulated and promulgated a series of policies and regulations, but it faces great difficulties in putting them into practice. In this retrospective look at the history of SO(2) control in China, we found that Chinese SO(2) control policies have become increasingly strict and rigid. We also found that the environmental policies and regulations are more effective when central officials consistently give environmental protection top priority. Achieving China's environmental goals, however, has been made difficult by China's economic growth. Part of this is due to the practice of environmental protection appearing in the form of an ideological "campaign" or "storm" that lacks effective economic measures. More recently, better enforcement of environmental laws and regulations has been achieved by adding environmental quality to the performance assessment metrics for leaders at all levels. To continue making advances, China needs to reinforce the economic and environmental assessments for pollution control projects and work harder to integrate economic measures into environmental protection. Nonetheless, China has a long way to go before economic growth and environmental protection are balanced.
Diabetic foot ulcers (DFUs) are a multifactorial complication of diabetes mellitus associated with impaired angiogenesis. Potentially effective treatments for such wounds are currently unknown. Cross-talk between pericyte and endothelial cell exosomes has been reported as a therapeutic strategy for treating DFUs. By regulating pericyte-endotheliocyte exosomes crosstalk, Angelica dahurica (AD) promoted angiogenesis and accelerated diabetic wound healing in this study. AD stimulated the migration and angiogenic tubule formation of human umbilical vein endothelial cells (HUVECs) by stimulating exosomes derived from human cerebrovascular pericytes (HBVPs), which was accompanied by increased protein expressions of Wnt4, β-catenin, and cyclinD1. In addition, the Wnt/β-catenin pathway inhibitor XAV939 reversed the activation of the Wnt4/β-catenin signalling pathway in HUVECs by AD. In the STZ-induced cutaneous wound rat model, AD enhanced angiogenesis and collagen deposition in vivo, resulting in a faster wound healing rate and a smaller wound area. AD concurrently promoted capillary formation by activating the Wnt4/β-catenin signalling pathway. AD promoted angiogenesis of HUVECs in vitro by regulating HBVPs-derived exosomes via the Wnt4/β-catenin signal pathway, thereby enhancing vascularization in regenerated tissue and promoting wound healing in vivo. The research indicated that AD could be used as a treatment for enhancing angiogenesis in diabetic wound healing.
We introduce a new Roper-Suffridge extension operator on the following Reinhardt domaingiven bywherefis a normalized locally biholomorphic function on the unit discD,pjare positive integer,ajare complex constants, andj=2,…,n. Some conditions forajare found under which the operator preserves almost starlike mappings of orderαand starlike mappings of orderα, respectively. In particular, our results reduce to many well-known results when allαj=0.
Purpose: Study on the effect of modified liankou Shengji powder on treating skin injury rats. Materials and Methods: Divided sixteen male SD rats were randomly into four groups: model group, normal group, modified liankoushengji powder group and Yunnan Baiyao powder group. The other three groups except the normal group were modeled as follows to form a mechanical damage animal model: the left three sides of the back were surgically cut into square full-thickness skin defects, deep into the skin, with a length of about 1 cm on the side. After the mold-building was successful, modified liankoushengji powder and Yunnan Baiyao powder were mixed with the appropriate amount of Vaseline into a paste and then applied to the affected area of rats for drug intervention. All rats in the model group were coated with Vaseline twice a day for 4 days. To observe the body temperature and the growth wounds by glare projection of all rats. Then to calculate the wound healing rate. And to detect Vascular Endothelial Growth Factor (VEGF) by ELISA. Results: In modified liankoushengji powder group, the body temperature was no observable change comparing with the normal group (p> 0.05). But the changes of the increased new capillary formation and the enhanced wound healing rate were significant differences comparing with the normal group(p<0.01).The enhanced concentration of VEGF was statistically significant (p<0.05).With little change in body temperature, there was no remarkable difference between the modified liankoushengji powder group and the Yunnan Baiyao powder group(p> 0.05). The changes of the increased new capillary formation and the enhanced wound healing rate were significant differences in the modified liankoushengji powder group comparing with the Yunnan Baiyao powder group(p <0.05).The enhanced
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