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Objectives To assess the prognostic value of neutrophil-lymphocyte ratio, lymphocyte–monocyte ratio and red cell distribution width in type 2 diabetics with COVID-19. Methods We collected the data of type 2 diabetics with COVID-19 treated in our hospital from January 28 to March 15, 2020 and performed a retrospective analysis. Using severity, duration of hospital stay, and the time required for nucleic acid results became negative as prognostic indicators, we explored the relationship between these inflammation-based markers and prognosis of type 2 diabetics with COVID-19. Results A total of 134 type 2 diabetics with COVID-19 were selected for this study. Correlation analysis showed that NLR, LMR and RDW were correlated with prognosis ( P < 0.05). In multivariate regression analysis after controlling for the relevant confounding factors, COVID-19 diabetes patients with higher NLR had heavier severity, longer duration of hospital stay, more time required for nucleic acid results became negative, and heavier hospital expenses ( P < 0.05). ROC curve result displayed that higher NLR predicted all prognostic indicators with statistical significance, and lower LMR predicted severe and extremely severe with statistical significance ( P < 0.05). Conclusions NLR is a more powerful and practical marker for predicting the prognosis of type 2 diabetic COVID-19 patients that is simple and fast.

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Accumulating evidence has revealed that various microRNAs are deregulated and involved in lung cancer development and metastasis. miR‐210 is implicated in several cancer progression. However, the detailed biological function and role of miR‐210 in lung adenocarcinoma remains unclear. Our current study was aimed to investigate the mechanism of miR‐210 in lung adenocarcinoma progression. We observed that miR‐210 was significantly upregulated in lung cancer cell lines (A549 and H1650) in comparison to BEAS‐2B cells. In addition, we found that miR‐210 was greatly elevated in lung adenocarcinoma tissues. Then, it was shown that overexpression of miR‐210 was able to promote lung cancer cell proliferation and colony formation ability while inhibitors of miR‐210 exhibited a reversed phenomenon. Subsequently, A549 and H1650 cell migration and invasion capacity were obviously restrained by miR‐210 inhibition whereas induced by miR‐210 mimics. Lysyl oxidase‐like 4 (LOXL4), a member of the secreted copper‐dependent amine oxidases has been found to be increased or decreased in different cancer types. Here, we confirmed that LOXL4 could serve as a downstream target of miR‐210 and miR‐210 promoted lung cancer progression via targeting LOXL4. In A549 and H1650 cells, knockdown of LOXL4 dramatically repressed lung cancer cell proliferation, migration, and invasion. In conclusion, our study implied that miR‐210 might indicate a new perspective for lung cancer.