miR‐210 promotes lung adenocarcinoma proliferation, migration, and invasion by targeting <b>lysyl oxidase‐like 4</b>

Xie, Songping; Liu, Gaoli; Huang, Jie; Hu, Haibo; Jiang, Wanli

doi:10.1002/jcp.28093

Cited by 29 publications

(20 citation statements)

References 30 publications

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“…MiRNAs are known to downregulate gene expressions by base-pairing with the 3′-UTR of targeted mRNAs [22]. For example, mirR210 promoted lung adenocarcinoma proliferation and metastasis by targeting LOXL4 [23]. MiR-342 regulated breast cancer progression via modulating ID4 [24].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: LncRNA SNHG7 promotes pancreatic cancer proliferation through ID4 by sponging miR-342-3p

Cheng

Fan²,

et al. 2019

Cell Biosci

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Background: Small nucleolar RNA host gene 7 (SNHG7) is a novel identified oncogenic gene in tumorigenesis. However, the role that SNHG7 plays in pancreatic cancer (PC) remains unclear. In this study, we aimed to investigate the functional effects of SNHG7 on PC and the possible mechanism. Methods: The expression levels of SNHG7 in tissues and cell lines were measured by RT-qPCR. Cell viability, apoptosis, migration and invasion were examined to explore the function of SNHG7 on PC. Bioinformatics methods were used to predict the target genes. The mechanism was further investigated by transfection with specific si-RNA, miRNA mimics or miRNA inhibitor. Tumor xenograft was carried out to verify the effects of SNHG7 in vivo. Results: We found that SNHG7 was overexpressed in both PC tissues and cell lines. High expression level of SNHG7 was correlated with the poor prognosis. SNHG7 knockdown inhibited the proliferation, migration and invasion of PC cells. Moreover, SNHG7 was found to regulate the expression of ID4 via sponging miR-342-3p. Additionally, this finding was supported by in vivo experiments. Conclusions: LncRNA SNHG7 was overexpressed in PC tissues, and knockdown of SNHG7 suppressed PC cell proliferation, migration and invasion via miR-342-3p/ID4 axis. The results indicated that SNHG7 as a potential target for clinical treatment of PC.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: LncRNA SNHG7 promotes pancreatic cancer proliferation through ID4 by sponging miR-342-3p

Cheng

Fan²,

et al. 2019

Cell Biosci

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“…MiR‐210 is an important regulator of various tumors, and aberrant miR‐210 expression has been identified in a variety of tumors. MiR‐210 facilitated lung adenocarcinoma growth, invasion, and metastasis via regulation of targeting lysyl oxidase‐like 4 36 . Up‐regulation of miR‐210 inhibited glioma cell growth and enhanced apoptosis through regulating switch‐insensitive 3 transcription regulator family member A (SIN3A) 37 .…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐210 targets FBXO31 to inhibit tumor progression and regulates the Wnt/β‐catenin signaling pathway and EMT in esophageal squamous cell carcinoma

et al. 2021

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Evidence from previous studies showed that the dysregulation of microRNA (miR) is frequently associated with tumor progression. The aberrant miR‐210 expression has been identified in a variety of tumors. However, its biological roles in esophageal squamous cell carcinoma (ESCC) still need further elucidation. Thus, in the current study we explore the roles of miR‐210 in ESCC progression. The findings of our study reveal that miR‐210 is down‐regulated in ESCC, which indicates poor prognosis and aggressive tumor progression. Moreover, miR‐210 restoration was found to enhance ESCC viability, invasion, and migration abilities. F‐Box only protein 31 (FBXO31) was confirmed to be one of the targets of miR‐210 in ESCC cells. Results also revealed that miR‐210 played crucial roles in regulating ESCC cell epithelial‐mesenchymal transition (EMT) and Wnt/β‐catenin signaling. In conclusion, data show that miR‐210 serves as an anti‐ESCC miR via down‐regulation of FBXO31 and regulation of EMT and Wnt signaling, suggesting that the miR‐210/FBXO31 axis may function as promising therapeutic targets and effective prognostic markers for ESCC patients.

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“…MiR-210 is one of the most widely studied miRNAs and has captured great attention since it has been shown to be associated with various biological processes and the development of different human diseases thus far [44]. The increasing literatures exploring the role of circulating miR-210 in LUAD have been proved miR-210 to be a noninvasive biomarker for LUAD detection [45][46][47]. In Tamiya H's research, it revealed the AUC value of exosomes miR-210 in the diagnosis of LUAD combined with pleural effusion was 0.81 [48].…”

Section: Discussionmentioning

confidence: 99%

Identification of Circulating miR-210 as a Promising Biomarker for Lung Adenocarcinoma

Xue

Hua²,

Jia

et al. 2019

Preprint

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Background: Lung adenocarcinoma (LUAD), with an increasing morbidity and mortality globally, is the most common histological subtype of lung cancer (LC). Early diagnosis of LUAD can significantly prolong survival time. Multiple researches have revealed that circulating miRNAs might be used as promising biomarkers for early detection of LUAD Material and Methods: A meta-analysis was conducted to find circulating miRNAs for early diagnosis of LUAD and summarized their diagnostic values based on GEO database. Further, by bioinformatics analysis we predicted the target genes of circulating miRNAs owning statistically significant, and explored the molecular regulation mechanisms and biological processes of the target genes in the pathogenetic of LUAD. Results: overall, six datasets were eligible, information on original expression levels of circulating miR-21, miR-155, miR-210, miR-126, miR-486, miR-182, and miR-17 extracted independently by two reviewers. Finally, we found circulating miR-210 had good diagnostic efficacy for LUAD detection, the combined AUC value was 0.83. We then predicted 480 overlapped genes of miR-210 at least 5 of 11 databases. Bioinformatics analysis showed statistically significant GO analysis 38 items and KEGG pathways 21 items. Response to hypoxia may be the mainly involved biological process of miR-210 in LUAD. Nine hub genes (FBXO, FBXL, MGRN1, ATG7, CUL3, RAB, ADAMTS, SEMA, THBS2) were obtained by construct PPI network. Conclusions: our study implied that circulating miR-210 may be a promising noninvasive biomarker for early detection of LUAD, but further researches are needed to validate the promising results and to identify specific biological processes and target genes.

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miR‐210 promotes lung adenocarcinoma proliferation, migration, and invasion by targeting lysyl oxidase‐like 4

Cited by 29 publications

References 30 publications

RETRACTED ARTICLE: LncRNA SNHG7 promotes pancreatic cancer proliferation through ID4 by sponging miR-342-3p

RETRACTED ARTICLE: LncRNA SNHG7 promotes pancreatic cancer proliferation through ID4 by sponging miR-342-3p

MicroRNA‐210 targets FBXO31 to inhibit tumor progression and regulates the Wnt/β‐catenin signaling pathway and EMT in esophageal squamous cell carcinoma

Identification of Circulating miR-210 as a Promising Biomarker for Lung Adenocarcinoma

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