In this clinical study, milk-based term infant formula (Similac Advance) with 4 g GOS/L was well-tolerated in terms of stool consistency and additional measures of gastrointestinal tolerance by newborn infants through the first 4 months of life.

Lipids in infant formulas are designed to mimic the composition of human milk and/or approximate the performance of the breastfed infant. Human milk lipids exhibit a complex, highly variable nature, varying by population, dietary intake, time of day, length of feeding and others. Continued understanding and characterization of human milk lipids has led to infant formula innovations aimed at a better comparison to human milk and/or improved dietary lipid utilization in the formula‐fed infant. The underlying aim of such innovation is the generation of outcomes as comparable to human milk feeding as possible. The present paper briefly reviews the current understanding of human milk lipid composition, with a focus on how this knowledge drives current and future innovations in the area of infant formula lipids.