A convergent and highly stereoselctive synthesis of macrolide framework of aldgamycin -M is described. The salient features of the synthesis are the utilization of enzymatic desymmetrization, Crimmin's non-Evans syn aldol reaction, Wittig olefination, Yamaguchi esterification and Ring closing metathesis reaction (RCM).

A highly stereoselective and an efficient approach for studies towards the synthesis of thermolide-6' has been described. The salient features of the synthesis are the utilization of desym-metrization protocol, Barton-McCombie deoxygenation and CÀC bond formation from an aldol reaction.

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A highly stereoselective and competent approach for studies towards the synthesis of Portentol has been described. The salient features of the synthesis are the utilization of desymmetrization protocol, Crimmin's non-Evans syn aldol reaction, CÀ C bond formation through an intermolecular Aldol reaction and Barton-McCombie deoxygenation.

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