A convergent and highly stereoselctive synthesis of macrolide framework of aldgamycin -M is described. The salient features of the synthesis are the utilization of enzymatic desymmetrization, Crimmin's non-Evans syn aldol reaction, Wittig olefination, Yamaguchi esterification and Ring closing metathesis reaction (RCM).

A highly stereoselective and an efficient approach for studies towards the synthesis of thermolide-6' has been described. The salient features of the synthesis are the utilization of desym-metrization protocol, Barton-McCombie deoxygenation and CÀC bond formation from an aldol reaction.

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A variety of novel thiazolidine derivatives (2-thioxothiazolidin-4-one and thiazolidine-2, 4-dione derivatives) have been prepared by using 2,4-diphenyl-2Hchromene-3-carbaldehyde and its derivatives as starting materials. This is the first example of the preparation of thiazolidine derivatives through this novel method. Structure evolution of the resulting thiazolidine derivatives leads to anticancer agents. Our preliminary data for some model compounds on three cancer cell lines (MCF7, A549 and B-16) suggested reasonable anticancer activity against the A549 and B-16 cell lines, with IC 50 values of 20.7 and 20.4 µM, respectively. This method is operationally simple and works with a diverse range of substrates.

A highly stereoselective and competent approach for studies towards the synthesis of Portentol has been described. The salient features of the synthesis are the utilization of desymmetrization protocol, Crimmin's non-Evans syn aldol reaction, CÀ C bond formation through an intermolecular Aldol reaction and Barton-McCombie deoxygenation.