No abstract

Objective: Obesity is one of the world's leading problems, which is major cause of Cardiovascular Diseases. During COVID -19 pandemic many young children and all age group people are getting challenged by obesity due stagnant life style. To treat such life threatening disorder natural remedies acquire prior position, Plant produce a good deal of secondary metabolites which have a benefited mankind in various ways, including treatment of diseases The present research work was focused on developing a natural remedy using an ancient plant with number of Tamarindus indica, proven activities in Traditional medicine.In the literature survey, it was found that Materials and Methods: flavonoids, sterols, tannins and alkaloids shown promising effects to tackle obesity by various mechanisms, Tamarindus indica has shown the presence of saponins, flavonoids, glycosides, amino acids, alkaloids. With the above evidence, this plant has been selected for screening of its antiobesity activity against high fat diet induced obesity in mice. Studies were conducted using aqueous extract of leaves (AETI) on high fat diet (butter) Tamarindus indica induced model of hyperlipidemia in mice.During 21 days time period AETI low and high Results and Discussion: doses were induced to respective animal groups along with butter where Atorvastatin has been taken as standard drug. Butter enhanced the Cholesterol and triglyceride, LDL levels. At the end of 21 days blood samples were collected from the animal through retroperitoneal route. Biochemical parameters of AETI have been revealed its antiobesity activity.

Objective: Diabetes is a complex heterogeneous disorder with chronic multiple illness which needs continuous medical management. Along with the medication life style modifications (diet, exercise) and patient self-management education is necessary not only for glyceamic control but also for prevention and delay of acute and long term complications. In this regard an observational study was carried out among 167 type 2 diabetic patients using a self-administered questionnaire in tertiary care hospital, Guntur. Methods: Patients of both genders in the age of 30-89 with co morbidities were included in the study. Data regarding social habits, medication and adherence, duration of diabetes, co-morbidities, presence of diabetic complications along with the prevalence of complications while practicing regular diet, exercise with medical adherence was collected and evaluated. Results: Among 167 patients 64.64 % were male and 35.36% were female. 14.4% of the populations are with diabetes from more than 17years. 65.3% of the patients don’t have alcoholic and smoking habit. Only 51.5% of the population was adherent to the medications. Hypertension is major co-morbidity existing among them. 82% of the study population reported macro vascular complication. The periodic prevalence rate(1-5years) of complications in type 2 diabetic patients who are adherent to medications and life style modifications was found to be 11.4% and the periodic prevalence rate of complications in patients who are either non-adherent to medications or life style modifications was 88.6%. Conclusion: Medical and life style adherence is strongly recommended which also must be promoted by conducting awareness programme and health care camps with continuous supervision by the family members over patients for healthy society.