Trichinellosis is a zoonotic disease of public health concern since it caused human outbreaks in many countries. Traditional therapy has many adverse effects in addition to the developing resistance. So, this necessitates finding effective natural alternatives. The study assessed the effect of Thyme extract (active constituent of thyme) on Trichinella spiralis in experimentally infected mice compared with Albendazole ® .One hundred and twenty Albino mice were classified into four groups of 30 mice each. G1: non-infected control, G2: infected untreated control, G3: albendazole treated, and G4: thyme extract treated. Mice were sacrificed on the 7 th day post infection for intestinal phase and on the 49 th & 60 th days post infection for muscular phase. Efficiency of treatment was assessed by parasitological and histopathological examinations.The results showed significant decrease in intestinal worms in all treated mice relative to untreated control group. Reduction rates regarding the intestinal phase was 96.7% in albendazole treated mice, followed by 33.4% in Thyme extract treated ones. Histological showed a significant decrease in muscle larvae relative to positive control mice showed by reduction rates of 86%, & 45.1% for albendazole and thyme respectively on 49 th dpi, and 99.9 %, & 68.6% respectively on 60 th dpi. There was improvement in intestinal and muscular architecture in all treated mice compared to positive control one, which was markedly best in albendazole treated ones.