The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

The mechanisms of dyspnea in congestive heart failure, although intensively investigated, have yet to be completely elucidated. Cardiac dyspnea has long been attributed to structural or functional changes in the lungs secondary to cardiac failure. Morphological alterations were first described by the pathologists of the 19th century. More recently, in the 20th century, this morphological approach has been complemented by determinations of pulmonary function during life.Prominent among the early observations of functional impairment were Peabody and Wentworth's correlation of cardiac dyspnea with decreased vital capacity (1), followed by Christie and Meakins' measurement of increased excursions of intrapleural pressure in heart failure (2), and the demonstration in experimental animals that pulmonary vascular congestion reduces pulmonary distensibility (3, 4). In vivo estimations of pulmonary blood volume in heart disease, however, have failed to demonstrate the expected correlations between increasing pulmonary vascular volume, increasing pulmonary vascular pressures and dyspnea (5-7). The limitations of existing methods may be responsible. Recently, emphasis has been placed upon the quantitative evaluation of the elastic properties of the lung in relation to cardiac dyspnea (8, 9). These studies have shown

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