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Studies iu this laboratory have demonstrated varying responses in heart rate during levarterenol-induced hypertension. A decreased bradycrotic response did not seem to depend on the age of the patient, the control level of arterial pressure or the percentage increase in mean arterial pressure. The present study was designed to evaluate the factors which govern the changes in heart rate during levarterenol infusion. P ATIENTS studied iu this laboratory have demonstrated varying responses in hea.t rate during levarterenol-induced hypertension. All those without obvious cardiovascular disease showed significant bradyeardia, while some patients with an elevated arterial pressure did not. Judson, Epstein, and Wilkins 1 have also noted this decrease in bradycrotic response during levarterenolinduced hypertension in patients with chronic hypertensive disease. The present study was designed to evaluate the relationship of the age of the patient, the initial level of arterial pressure, the per cent increase in arterial pressure, and the presence of arteriosclerosis on the response of the heart rate during levarterenol administration. METHODSOne hundred eight patients were studied. Fiftyfive patients were without any manifest cardiovascular disease. Forty-four were young (group 1) and 11 were elderly (group 2). Eleven patients showed clinical evidence of arteriosclerosis with a