Diethyl Phthalate (DEP) is used as a plasticizer, a detergent base, in aerosol sprays, as a perfume binder and after shave lotion. It is known to be a contaminant of fresh water and marine ecosystem. Therefore, a study was designed to determine the acute toxicity effects of DEP on a fresh water fish, Clarias gariepinus fingerlings. The fish was treated with 50, 75, 100 and 150 µg/l. DEP was dissolved in distilled water to determine the LC 50. There was 100% mortality observed in 150 µg/l. The LC 50 of DEP was estimated at log toxicant concentration as 2.217, 2.734, 3.435 and 3.931 µg/l at 24, 48, 72, 96 h and 1.871µg/l for the total death. This shows that the impacts are dose and time dependent with respect to marked reduction in mortality rate. At sub-lethal concentrations of the test substance at 30, 40, 60 and 80 µg/l in a renewal bioassay system, the water and the test compound were changed intermittently. One group was maintained as a control in dechlorinated water. There was significant difference (P < 0.05) in brain and muscle AchE activity compared to the control. The liver ACP activity was statistically significant (P < 0.05) at day 15 while the muscle ACP in other treatment groups showed no significant difference (P > 0.05). Liver AST showed no significance in all treated groups (P > 0.05) and liver ALT activity was statistically significant (P < 0.05) at day 30 only. The haematological parameters (HB, PCV, RBC and WBC) carried out showed that haemoglobin and erythrocyte levels estimated in all treatment groups to the duration of exposure showed no significant difference (P > 0.05) compared to the control. The park cell volume showed a significant difference (P < 0.05) at day 30 only. The leucocyte count throughout the exposure period showed that the mean values are statistically significant (P < 0.05) at day 15 only compared to the control. The mean cell volume (MCV) showed a significant difference at day 15 (P < 0.05) whereas mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC) showed no significant difference (P > 0.05) throughout the exposure period. No significant difference was seen between the lymphocytes and the neutrophils. In day 0 and 15 only, the monocytes and the lymphocytes showed a significant difference (P < 0.05). The gill damages indicated toxicity of DEP with raised lamella, oedema of the lamella epithelia, loss of lamellar epithelium, mild oedema and raising of the filament. The liver damage showed focal necrosis and vacuolization, hepatocyte degeneration in the liver. These alterations may have long term effects on that that are continuously exposed to DEP in the aquatic environment.
One hundred and fifty-two malaria-infected pregnant women whose pregnancies had advanced to the 6th month were randomised into two study groups - supplemented and placebo groups, after obtaining their approved consents. Ten thousand international units of vitamin A soft gels were administered to the supplemented group three times per week. Vitamin A soft gels devoid of their active ingredients were administered thrice weekly to the placebo group. Two hundred thousand international units of vitamin A was administered to the supplemented groups within 8 weeks postpartum. Placebo was given to the control group at same time after delivery. The regimen was continued in the two groups at three-month intervals until 12 months. Quarterly, 3 ml of venous blood was collected from each infant in the two groups and was used for the estimation of hemoglobin concentrations and determination of blood glucose levels. Hemoglobin concentrations were estimated using hemiglobincyanide method while the blood glucose levels were determined with a glucometer. Analysis of variance, Fisher's least significant difference and t-test were used for data analysis. Statistical significance was established at p < 0.05. Both hemoglobin concentrations and blood glucose levels were significantly (p < 0.05) higher in the supplemented group than in the placebo group. The malaria infection mitigating effects of maternal vitamin A supplementation have been established in the present study and supported by previous studies. Vitamin A supplementation, fortification of foods with vitamin A and diversification of diets, are advocated for maintenance of good health and protection against some infectious diseases.
Forest wastes are renewable resources that can serve as sources of energy for heat and electricity generation. How these materials are managed in order to reduce their contribution to the release of greenhouse gases, reduce subsequent climate change challenges and their potential use in bio-energy production has remained a myth in Nigeria. In this paper, extensive review of the literature was carried out to arrive at the findings. More than 93% of all wood processing industries in Nigeria are sawmills. In addition to sawmills there are the plywood mills, furniture processing industries, and particleboard mills. Sawdust is the major waste generated from wood processing in the various processing units. Currently, the most popular waste management practice in Nigeria is burning. Dumping in open spaces, riverbanks, and water bodies is also obtainable. There is no record of wood waste recycling for bio-fuel production at the moment. Wood wastes are reused for agricultural production (mulching, manure) and as firewood. These actions contribute to the release of greenhouse gases and subsequently contribute to global warming. There are policies and agencies put in place to address this menace but implementation is a problem. An increase in proper waste management education and awareness, and aid from developed countries in terms of providing the technology needed for recycling and incineration, will go a long way in ensuring the safety (from climate change and consequences) of the local people, the environment, and the world at large.
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