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Background Natural and vaccine-induced immunity will play a key role in controlling the SARS-CoV-2 pandemic. SARS-CoV-2 variants have the potential to evade natural and vaccine-induced immunity. Methods In a longitudinal cohort study of healthcare workers (HCWs) in Oxfordshire, UK, we investigated the protection from symptomatic and asymptomatic PCR-confirmed SARS-CoV-2 infection conferred by vaccination (Pfizer-BioNTech BNT162b2, Oxford-AstraZeneca ChAdOx1 nCOV-19) and prior infection (determined using anti-spike antibody status), using Poisson regression adjusted for age, sex, temporal changes in incidence and role. We estimated protection conferred after one versus two vaccinations and from infections with the B.1.1.7 variant identified using whole genome sequencing. Results 13,109 HCWs participated; 8285 received the Pfizer-BioNTech vaccine (1407 two doses) and 2738 the Oxford-AstraZeneca vaccine (49 two doses). Compared to unvaccinated seronegative HCWs, natural immunity and two vaccination doses provided similar protection against symptomatic infection: no HCW vaccinated twice had symptomatic infection, and incidence was 98% lower in seropositive HCWs (adjusted incidence rate ratio 0.02 [95%CI <0.01-0.18]). Two vaccine doses or seropositivity reduced the incidence of any PCR-positive result with or without symptoms by 90% (0.10 [0.02-0.38]) and 85% (0.15 [0.08-0.26]) respectively. Single-dose vaccination reduced the incidence of symptomatic infection by 67% (0.33 [0.21-0.52]) and any PCR-positive result by 64% (0.36 [0.26-0.50]). There was no evidence of differences in immunity induced by natural infection and vaccination for infections with S-gene target failure and B.1.1.7. Conclusion Natural infection resulting in detectable anti-spike antibodies and two vaccine doses both provide robust protection against SARS-CoV-2 infection, including against the B.1.1.7 variant.

The purpose of this study was to determine whether hypermnesia (improved net recall over time) can be differentially affected by manipulating the nature of tasks performed during the intervals between successive recall trials. In Experiment 1, all subjects were asked to imaginally encode separate words and were tested three times for recall. The control group (no interpolated task) produced the hypermnesia effect. Both groups performing interpolated tasks showed sig· nificantly lower recall. A second experiment was conducted in order to replicate these results and to examine the effects of intertest rehearsal on hypermnesia. In Experiment 2, subjects were asked to encode pairs of words using interactive·imagery instructions. Six different interpolated task conditions were employed, varying in the degree to which subsystems of working memory were used. Groups performing imaginal interpolated tasks showed no hypermnesia, whereas those performing nonimaginal tasks did. These findings suggest that access to working memory (see Baddeley, 1986) is not necessary for hypermnesia.Ballard, in 1913, reported an effect in which the net recall of poetry seemed to increase over time, despite the fact that no subsequent learning or rehearsal trials had been given during the retention interval. He described this phenomenon as reminiscence. Subsequent attempts at replicating Ballard's fmdings provided only mixed results (e.g., Buxton, 1943), and investigations of the effect ceased for several years. Buxton's (1943) criticisms of the research procedures used by various experimenters centered around the idea that subjects might be engaging in covert rehearsal or review during the retention intervals and that this might account for the varied results in reminiscence research. He suggested that control of rehearsal during the retention interval might be accomplished either by occupying subject'S minds during retention with such tasks as prose reading, problem solving, and so forth, or by having subjects recall the items in repeated recall trials, thereby ensuring rehearsal during the retention interval.The past decade has brought an accumulation of evidence that must be taken as indicating a strongly renewed

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