The aim of the present study is to demonstrate the anxiolytic and anticonvulsant effects of a hydroalcoholic extract obtained from the aerial parts of Cissus sicyoides L. (CS) (Vitaceae) on male and female mice using several behavioral assays. Groups of males and females treated via intraperitoneal (IP) with doses of 300, 600, and 1000 mg/kg of the extract showed significant action in the elevated plus-maze (EPM), time spent in the open arms, and number of entries in the open arms. The board-hole test also showed a significant increase in the time spent in head-dipping and in marble-burying test of the number of marbles buried. The same treatment increased the duration of sleeping time induced by sodium pentobarbital and also showed a significant increase in protection against pentylenotetrazole-induced convulsions. These results indicate an anxiolytic and anticonvulsant-like action from C. sicyoides L. extract on mice, probably due to the action of flavonoid(s), Linalool, and α-tocopherol present in the C. sicyoides leaves.
A low prevalence of dental caries was observed among the children studied at the initial examination, but around 20% of these children presented with new disease during the period of the study. Amongst children with lesions at the start, the presence of caries almost doubled between examinations.
Cárie dentária; Pré-escolar; Condições sociais; Serviços de saúde bucal. Dental caries; Preschool ; Social conditi ons; Dental health services. Objecti ve: To analyze comparati vely the distributi on patt ern of dental caries in preschoolers living in areas assisted by the Family Health Strategy of the city of Recife, PE, in two sanitary districts. Method: An epidemiological survey of dental caries was conducted in 2006 in 2,020 children aged 18-36 months and 5 years enrolled in the Family Health Centers of the Sanitary Districts II and IV of the city of Recife, PE. The dmft index was used as recommended by the World Health Organizati on and the Brazilian Ministry of Health. A probabilisti c sample by conglomerates (families) was used in one stage. It was calculated frequency distributi on, tests for comparison of the means (Student's t-test and ANOVA) and proporti ons (chisquare) with 5.0% signifi cance level, and ponderati on factors for sample representati veness. The analyses were produced by district and by microregions. Results: In both districts, the prevalence and dmft means were high, being 29.7% among children aged 18-36 months and 63.8% among those aged 5 years. Comparing the districts, the dmft ranged from 0.99 to 1.15 (18-36 months) and from 3.01 to 3.65 (5 years). However, the prevalence rati os did not show signifi cant diff erences between districts or ages. Comparing the microregions, the diff erences in caries prevalence and severity occurred only at the age of 5. Conclusion: The caries indicators used in this study revealed the existence of niches of children with worse oral health conditi ons in poor areas with apparent socioeconomic homogeneity, suggesti ng a reorientati on of collecti ve and individual interventi ons in areas/microareas in which higher indices are observed.
OBJETIVOS: verificar a relação da experiência da doença cárie com o grau de ocorrência de Streptococcus mutans, o fluxo salivar e a capacidade tampão da saliva em 111 adolescentes sadios atendidos no Setor de Puericultura do Hospital das Clínicas de Pernambuco MÉTODOS: realizou-se o exame intraoral e o preenchimento de ficha clínica, para determinação do índice CPO-S (Número de superfícies dentárias cariadas, perdidas ou com extração indicada e restauradas). Em seguida coletou-se a saliva para determinação do fluxo salivar e da capacidade tampão. A raspagem dos dentes anteriores foi realizada para quantificação de Streptococcus mutans presente na placa bacteriana. RESULTADOS: a população avaliada foi predominantemente de baixa atividade de cárie, apresentando capacidade tampão da saliva normal e fluxo salivar deficiente. O número de S. mutans da placa bacteriana foi superior a 105 UFC/mg, na maioria da população estudada. CONCLUSÕES: a atividade de cárie foi inversamente proporcional à capacidade tampão e diretamente proporcional a presença de Streptococcus mutans presentes na placa bacteriana. A baixa atividade de cárie na população estudada pode ser atribuída à boa condição do meio bucal promovida pelo número de escovações diárias com dentufícios fluoretados.
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