Gangliogliomas are central nervous system (CNS) tumors with a neuronal and glial component considered grade 1 according to the World Health Organization (WHO) classification. On the other hand, oligodendrogliomas are diffuse infiltrating gliomas (CNS WHO grade 2 or 3) characterized by both an isocitrate dehydrogenase mutation and 1p/19q co-deletion. There have been some cases with the coexistence of these two tumors. Here, we present the case of a low-growing left frontoparietal brain tumor with a definite diagnosis of ganglioglioma (CNS WHO grade 1) and oligodendroglioma (CNS WHO grade 2) with areas of anaplastic oligodendroglioma (CNS WHO grade 3) in a patient with long-standing epilepsy.

Glucose provides the necessary fuel to cover the physiological functions of the organism. In the brain, glucose represents the main energy supply through the generation of adenosine triphosphate, with oxygen and glucose being the main components involved. The imbalance in glucose levels in the central nervous system produces substantial changes in metabolism. Hypoglycemia, or decreased blood glucose levels below 50 mg/dl, is accompanied by symptoms such as decreased performance of cognitive tasks such as verbal fluency, reaction time, arithmetic ability, verbal memory and visual, in addition to excitotoxicity, oxidative stress, neuroinflammation and apoptosis. Hyperglycemia participates in some cardiovascular diseases, neuropathy, nephropathy, retinopathy. Changes in glucose metabolism must be regulated and considered in order to obtain the best treatment for different pathologies, such as infections, non-infections, traumatic, primary or acquired.

Nelson's syndrome (NS) is an uncommon disease occurring as a complication of bilateral adrenalectomy (BLA) in patients with persistent Cushing's disease (CD) due to an adrenocorticotropin-producing pituitary tumor. The first reports of this syndrome were done in the 50s, although its pathophysiology is still not understood. Every year, between 1.8 and 2.6 cases are thought to occur per million people. It is characterized by hyperpigmentation, elevated adrenocorticotropic hormone (ACTH) plasma levels, and typical signs and symptoms related to pituitary adenomas, such as visual deficits due to optic pathway compression or decreased hormone production from the adenohypophysis. NS represents a challenge due to the lack of accepted diagnostic criteria and the complexity of its treatment. Moreover, the development of stereotactic radiosurgery (SRS) in the last few years has become an essential but controversial strategy for this syndrome. This review presents a comprehensive overview of NS.