New carotenoids, cryptocapsin-5,6-epoxide,
3′-deoxycapsanthin-5,6-epoxide,
and cryptocapsin-5,8-epoxides, have been isolated from the ripe fruits
of red mamey (Pouteria sapota). Cryptocapsin-5,6-epoxide
was prepared by partial synthesis via epoxidation of cryptocapsin,
and the (5R,6S)- and (5S,6R)-stereoisomers were identified by HPLC-ECD analysis.
Spectroscopic data of the natural (anti) and semisynthetic
(syn) derivatives obtained by acid-catalyzed rearrangement
of cryptocapsin-5,8-epoxide stereoisomers were compared for structural
elucidation. Chiral HPLC separation of natural and semisynthetic samples
of cryptocapsin-5,8-epoxides was performed, and HPLC-ECD analysis
allowed configurational assignment of the separated stereoisomers.
From an extract of red mamey (Pouteria sapota) β-cryptoxanthin-5,6-epoxide, β-cryptoxanthin-5',6'-epoxide, 3'-deoxycapsanthin, and cryptocapsin were isolated and characterized by UV-vis spectroscopy, electronic circular dichroism (ECD), nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry (MS). Epoxidation of β-cryptoxanthin delivered the β-(5'R,6'S)- and (5'S,6'R)-cryptoxanthin-5',6'-epoxides, which were identified by HPLC-ECD analysis. These carotenoids among others are quite common in the fruits of Central America, and as they are natural provitamins A, they should play an important role in the diet of the mostly vitamin A deficient population of this region.
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