Urethral strictures after prostate cancer radiotherapy should be diagnosed and treated in time for long-term preservation of renal function. The rate of radiogenic urethral strictures (3.4%) is equivalent to those after radical prostatectomy. Due to a high rate of recurrences, urethrotomy has a limited importance after irradiation.

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Whole pelvis irradiation was a significant predictor only for early GU (OR: 1.77; p¼0.006) and early GI complications (OR: 3.20; p<0.001). Finally, the number of lymph nodes removed was associated with both early and late GI complications (OR: 1.12, p¼0.02; and OR: 1.18, p¼0.01).CONCLUSIONS: At long-term follow-up, the risk of complications is not negligible, despite being mostly low grade. Concomitant HT represents a significant predictor of both early and late high-grade complications. Whole pelvis irradiation is a significant risk factor for early high-grade complications, whereas number of nodes removed is significantly associated with late high-grade complications