The aim of this study is to create a computational model of the human ureteral system that accurately replicates the peristaltic movement of the ureter for a variety of physiological and pathological functions. The objectives of this research are met using our in-house fluidstructural dynamics code (CgLes-Y code). A realistic peristaltic motion of the ureter is modelled using a novel piecewise linear force model. The urodynamic responses are investigated under two conditions of a healthy and a depressed contraction force. A ureteral pressure during the contraction shows a very good agreement with corresponding clinical data. The results also show a dependency of the wall shear stresses on the contraction velocity and it confirms the presence of a high shear stress at the proximal part of the ureter. Additionally, it is shown that an inefficient lumen contraction can increase the possibility of a continuous reflux during the propagation of peristalsis.

The ureter and its peristalsis motions have long been of significant interest in biomechanics. In this article we review experimental, theoretical, and numerical studies of the behavior of the ureter together with its mechanical properties, emphasizing studies that contain information of importance in building a virtual simulation tool of the complete ureter that includes its complex geometry, nonlinear material properties, and interaction with urine flow. A new technique to model the contraction of a ureter, which directly applies wall forces to model pacemaker activities, is presented. The required further steps to capture the full complex movement of the peristalsis are discussed, aiming to construct a computational platform that will provide a reliable tool to assist in the investigation and design of material devices (stents) for the renal system.