2-Methoxytetrahydropyran (1), -thiopyran (2) and -selenopyran (3) have been chosen as model compounds to investigate the origin of the anomeric effect (AE). The impacts of the hyperconjugation, electrostatic and steric interactions on the conformational preferences of compounds 1 -3 have been analysed by means of complete basis set-4, hybrid-density functional theory (B3LYP/6-311 þ G**) based methods and natural bond orbital (NBO) interpretation. Both levels of theory showed that the axial conformations of compounds 1 -3 are more stable than their equatorial conformations. The Gibbs free energy difference (G eq -G ax ) values (i.e. DG eq -ax ) between the axial and equatorial conformations increase from compound 1 to compound 2 but decrease from compound 2 to compound 3. Based on the NBO results obtained, the AE associated with the electron delocalisation [i.e. S(endo-AE eq þ exo-AE eq ) 2 S(endo-AE ax þ exo-AE ax )] increase slightly from compound 1 to compound 2 but decrease from compound 2 to compound 3. Similar trend is also observed for the differences between the calculated total steric exchange energy values [i.e. D(TSEE) eq -ax ]. On the other hand, the calculated differences between the dipole moment values of the axial and equatorial conformations [i.e. D(m eq -m ax )] decrease from compound 1 to compound 3. These findings led to the proposal that the AE associated with the electron delocalisation (the hyperconjugation effect) is more significant for the explanation of the conformational preferences of compounds 1 -3 than the electrostatic model. The correlations between the AE associated with the electron delocalisation, bond orders, TSEE, DG eq -ax , dipole-dipole interactions, structural parameters and conformational behaviours of compounds 1 -3 have been investigated.

No abstract