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Primary eosinophilic gastrointestinal disorders (EGIDs) are emerging inflammatory diseases of unknown etiology which may involve any part of the gastrointestinal (GI) tract and lead to a pathological eosinophilic mucosal infiltration. 1,2 Although their pathogenic mechanisms are mostly unknown, EGIDs seem to be commonly associated with atopy. 3 Based on the GI tract involved, EGIDs are classified in eosinophilic esophagitis (EoE) and non-esophageal EGIDs. EoE is currently considered one of the major causes of upper gastrointestinal morbidity, with a significant burden on patients, caregivers, and the healthcare system. 4 Children with non-esophageal EGIDs may present non-specific GI symptoms, mainly depending on depth (mucosal, muscular, and serosal forms) and the extension of the inflammatory process. 1 On the contrary, patients with EoE generally develop symptoms due to esophageal dysfunction and inflammation. Although the prevalence is still unknown, several studies reported that EGIDs may be associated with malnutrition, including undernutrition, inadequate intake of vitamins and/or minerals, and overweight/obesity. 4 Vitamin D deficiency has also been reported in

Background: gastric pneumatosis is a rare sign with a primarily radiological diagnosis. In newborn infants, this finding should raise the suspicion of necrotizing enterocolitis, which represents a serious clinical condition with high morbidity and mortality. However, other causes of gastric pneumatosis are reported in literature, including intramural displacement of a feeding tube. In this report we present a case of gastric pneumatosis in a preterm boy admitted to our NICU. Case presentation: the baby appeared pale and poor responsive during the first days of life on positive pressure ventilation and gavage feeding. A distended upper abdomen with bloody and biliary gastric aspirates was noted; no bloody stools were reported. Blood cultures, cerebrospinal fluid culture and blood cell count were normal; acute phase proteins were negative on serial determinations. Abdominal X-Ray showed gastric pneumatosis with displacement of the feeding tube and no other pathological findings in the rest of the bowel. After few days of conservative management, the baby improved dramatically. Conclusions: we suggest that the cause of this clinical picture could have been a mechanical lesion in gastric mucosa caused by the feeding tube; positive pressure ventilation then could have raised intragastric pressure, leading air to diffuse between the layers of the gastric wall.