The development, dissemination and implementation of high technologies in Lithuanian market is a complex process within national innovation system. The comprehension of trends in the global market requires investigation of implications of regionalization, globalization and internationalization phenomena. EU policies significantly support R&D though the efficiency of innovation commercialization is not far reaching comparing with the leading countries in high technologies development, dissemination and implementation. To overcome this European paradox and social, environmental challenges, EU Commission ascertained Innovation Union 2020 Strategy. The objective of this article is to explore the EU regionalization impact on Lithuanian high technology development, dissemination and implementation performance, therefore the value chain theories relevant for the global markets aspect are reflected.