Comparative therapeutic use of Risedronate and Calcarea phosphorica -allopathy versus homeopathy -in bone repair in castrated ratsComparação do uso terapêutico de Risedronato e Calcarea phosphorica -alopatia versus homeopatia -no reparo ósseo em ratos castrados Cristina Werkman* Giselle Segnini Senra* Rosilene Fernandes da Rocha** Adriana Aigotti Haberbeck Brandão*** ABSTRACT: Osteoporosis, a disease characterized by progressive bone loss, has been the target of several studies in the past few years. It results in a much higher risk for fractures and might cause slower bone lesion healing. The aim of this work was to study the effects of Risedronate (allopathic medicine) and Calcarea phosphorica 6CH (homeopathic medicine) on the repair of bone lesions in male rats with osteoporosis induced by castration. Eighty-four three-month-old rats were used divided into four groups of twenty-one animals each. Three groups where castrated and one group was submitted to Sham surgery. One month later, cortical lesions were made in all animals' tibiae and, after one day, the different experimental treatments began according to the following groups: CR -castrated/Risedronate (1 mg/kg/day); CCp -castrated/Calcarea phosphorica 6CH (3 drops/day); CP -castrated/placebo and SP -Sham/placebo. The animals were sacrifi ced at seven, fourteen and twenty-eight days after the beginning of the treatments and had their tibiae removed. Digital radiographs of the tibiae were taken and analyzed in order to evaluate the optical density of the defect area. Then, they were decalcifi ed and processed for histological and histomorphometrical analysis. The data were submitted to ANOVA, and to the Tukey and Dunnett tests (5%). The allopathic and homeopathic treatments led to different bone formation as regards remodeling and maturation aspects. Further research is necessary to access the resistance and quality of the newly formed bone. DESCRIPTORS:Allopathy; Homeopathy; Calcarea phosphorica; Fracture healing. RESUMO:A osteoporose, doença caracterizada pela perda de massa óssea, tem sido alvo de estudos nos últimos anos. Fraturas decorrentes da osteoporose são muito comuns e podem apresentar consolidação mais lenta. O objetivo deste trabalho foi avaliar o efeito do risedronato (medicamento alopático) e da Calcarea phosphorica 6CH (medicamento homeopático) no reparo de lesões ósseas em ratos com osteoporose induzida por castração. Para tanto, foram utilizados oitenta e quatro ratos, com três meses de idade, separados em quatro grupos de vinte e um animais, sendo três grupos submetidos à castração e um grupo a falsa cirurgia ("Sham"). Um mês após a cirurgia, foram realizadas lesões corticais na tíbia de todos os animais e, a partir do dia seguinte, os tratamentos experimentais foram iniciados de acordo com os seguintes grupos: CR -castrado/risedronato (1 mg/kg/dia); CCp -castrado/Calcarea phosphorica 6CH (três gotas/dia); CP -castrado/placebo e SP -"sham"/placebo. Os animais foram sacrifi cados aos sete, catorze e vinte e oito dias após o início do trat...

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A 17-year-old white boy was seen at the outpatient clinic of the Discipline of Stomatology, Sa˜o Jose´dos Campos Dental School-UNESP, complaining of the presence of nodules in the mouth, nasal, and palpebral mucosae, unaltered since birth. Clinical examination revealed painless mucosal nodules of variables sizes on the lips, buccal mucosa, and lateral borders of the tongue and palate, whose color was similar to that of the adjacent mucosa (Fig. 1). Papules were also present in the nasal mucosa and on the left lower eyelid (Fig. 2). The lips had been submitted to cosmetic surgery years before but without histopathological analysis of the removed material. Physically, the patient exhibited a tall stature and evidently elongated upper and lower limbs, in addition to manifestations of scoliosis. The patient was otherwise apparently well with no systemic symptoms and had no other dermatologic lesions.A biopsy was taken from one of the nodules located on the left lateral border of the tongue and sent for histological analysis (Fig. 3).