Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation is currently recommended for the estimation of glomerular filtration rate (GFR). This retrospective study aimed to evaluate the correlation between creatinine and cysC-based estimated GFRs and measured GFR in healthy adults. Consecutive healthy adults who were accepted as voluntary kidney donors at our center between January 2008 and December 2012 were included in the study. The 336 individuals who comprised the study population had a mean age of 41.6 ± 11.8 years, male:female ratio 1:1.7, mean creatinine 0.9 ± 0.1 mg/dl, and mean cysC 0.8 ± 0.1 mg/dl. Mean measured GFR by Tc-99m diethylenetriaminepentaacetic acid using Gates method was 98.4 ± 21.2 ml/min/1.73 m2. The mean ± standard deviation of eGFRs by various formulae were as follows: Cockcroft–Gault (CG) = 88.1 ± 15.9 ml/min/1.73 m2, Modification of Diet in Renal Disease (MDRD) = 78 ± 14.7 ml/min/1.73 m2, CKD-EPI creatinine = 88.1 ± 15.5 ml/min/1.73 m2, CKD-EPI cysC = 97 ± 19.9 ml/min/1.73 m2, CKD-EPI creatinine-cysC (CKD-EPI cr-cysC) = 92.5 ± 14.1 ml/min/1.73 m2. The CKD-EPI cr-cysC equation had the highest accuracy, with 43% and 72% of values lying within ±10% and ±20% of the measured GFR, respectively. Bland–Altman analyses for levels of agreement showed least bias with CKD-EPI cysC overall and among females, while among males, CKD-EPI creatinine equation had the least bias. The CKD-EPI equation showed a higher performance than the MDRD and CG equation in GFR estimation of a healthy population. Among CKD-EPI equations, CKD-EPI cr-cysC had the highest accuracy and CKD-EPI cysC the least bias.

BACKGROUND The role of serum uric acid in cardiovascular and renal diseases has been intensively investigated. High serum uric acid has been indicated as a risk factor for CAD and as an independent prognostic factor of poorer outcomes in patients with verified CAD. MATERIALS AND METHODS Study was done in one hundred patients with myocardial infarction admitted at Government Rajaji Hospital, Madurai. Detailed history and clinical examination done. Uric acid was estimated. The relationship of uric acid with severity of myocardial infarction, treatment response, ejection fraction, arrhythmia and hypotension were studied. RESULTS A total of 100 patients was recruited to the study. The mean age and mean uric acid level of the study sample was 56 years and 5.9 mg/dL, respectively. There were 65 (65%) males and 35 (35%) females. Males had higher uric acid level than females (p<0.05). Those who had SUA >7 mg/dL (n=17) had low ejection fraction, which was statistically significant p value, 0.03. Among the 15 patients belonging to KILLIP IV, 12 had SUA values more than 7 mg/dL (p<0.05). CONCLUSION Measuring serum uric acid level at admission for acute myocardial infarction patients we can stratify them and can treat effectively.

BACKGROUND Serum magnesium levels in critically-ill ICU patients and its correlation with the prognosis of the patients have been studied. Low serum magnesium levels were seen in critically ill and it was associated increased mortality. MATERIALS AND METHODS It is a prospective observational study involving 100 critically-ill medical patients admitted in Intensive Medicine Care Unit of Government Rajaji Hospital, Madurai. A detailed medical history, clinical examination, random blood sugar, serum electrolytes (sodium, potassium, magnesium, calcium), ECG, ABG analysis, complete haemogram and APACHE scoring were done. Chisquare test was used to assess the statistical significance of qualitative data.

BACKGROUNDAcute kidney injury following administration of iodinated contrast (CI-AKI) has been referred to as contrast induced nephropathy (CIN). Ischemic preconditioning (IPC), transient brief episodes of ischemia before a subsequent prolonged ischemia/reperfusion injury, has been shown to reduce the extent of organ damage. Several studies have demonstrated the tissue-protective effects of remote ischemic preconditioning (RIPC) in various target organs, including the kidneys. The aim of this study is to assess if remote ischemic preconditioning reduces the incidence of contrast induced AKI in patients with STEMI undergoing coronary angiogram. MATERIALS AND METHODSThe study was conducted in 100 patients (50 cases and 50 control) who were undergoing coronary angiogram (CAG) following acute ST elevation myocardial infarction in Govt. Rajaji Medical College, Madurai. Test group underwent RIPC (Remote Ischemic preconditioning) and control group underwent sham preconditioning prior to procedure whereas both test and control groups received normal saline infusion-1 ml/kg/hr, beginning 12 hours before CAG till 12 hours after coronary angiogram (CAG). Both groups were followed with serial renal function tests for next 72 hrs after CAG.