Summary Cytomixis associated with chromosomal anomalies was recorded in the meiotic division of pollen mother cells of the wild genotypes of Chlorophytum tuberosum (Roxb.) Baker for the first time. The migration of chromosomal substances was more prevalent in Meiosis-I than Meiosis-II. Cytomixis has been found both in juxtaposed cells by direct contact as well as between remote cells through cytoplasmic strands. During cytomixis, various chromosomal abnormalities, such as chromosomal stickiness, laggards, chromosomal bridges, unequal separation of chromosome, micronuclei formation and loss of chromosome, were recorded. A significant number of empty pollen formations leading to pollen sterility was recorded which is assumed to be a direct result of cytomixis.
This research has revealed the molecular docking and dynamics study with few phytomolecules against the human tyrosinase enzyme protein in order to control hyperpigmentation and skin tone in the future. This study set out to find certain phytomolecules that have the capacity to attach to the protein model for the tyrosinase enzyme and block the enzyme's ability to function. We took into account all nine molecules in total, coupled with a protein model of the tyrosinase enzyme, for docking, with energy ranges between -5.3 and -7.4 Kcal/mol. The greatest lowest binding energy for quercetin was -7.4 Kcal/mol. With a model protein, this molecule displayed a variety of interactions, including Van der Waals, conventional hydrogen bonds, covalent bonds, and carbon hydrogen bonds. In this interaction, 3 hydrogen bonds were discovered. The other compounds, such as kaempferol and chlorogenic acid, also demonstrated correct binding with the model tyrosinase and had -7.2 Kcal/mol energy with 3 and 5 hydrogen bonds, respectively. Quercetin, Kaempferol, and Chlorogenic acid are therefore thought to be far more potent than Benztropine and may be used in further clinical research.
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