Coumarin derivatives possess a wide spectrum of biological activities (1-3). Also, it is well documented that pyrazoles, pyrazolin-5-ones, 4-thiazolidinones and 1,3,4-oxadiazoles display pronounced antioxidant (4-6) and antineoplastic activity (7-10). In view of the considerable importance of the coumarins and heterocycles mentioned above, the present work is aimed at the design and synthesis of new heterocyclic compounds bearing coumarin moiety. Moreover, the study includes testing of target compounds for their cytotoxic activity against Dalton's lymphoma ascites (DLA) and Ehrlich ascites carcinoma (EAC) cells.
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