Beta 2-Agonists are safe and effective bronchodilator drugs. Their major adverse effects of skeletal muscle tremor, tachycardia and various metabolic effects are mediated by beta-adrenoceptor stimulation and are reversible. Skeletal muscle tremor is the most frequent dose-limiting side effect. It may be reduced by commencing treatment with a low dose and if it persists another beta 2-agonist may be tried. Other side effects such as cardiac arrhythmias and reduction in PaO2 are a serious potential problem in some susceptible asthmatics. However, they are infrequent or of a mild degree and are generally outweighed by the good control of asthma produced by beta 2-agonists. Side effects from beta 2-agonist therapy can be minimised by use of the inhaled route which selectively delivers the drug to the airways. Furthermore, selective tolerance develops to their side effects. The dose of a beta 2-agonist should be assessed on the basis of therapeutic effect and the level of tolerance to its side effects. Recommended doses of beta 2-agonists used for long term therapy do not cause clinically significant desensitisation of airway beta-adrenoceptors, although this may become a relevant problem in patients who are regularly receiving very high doses. Intravenous beta 2-agonists have a place in the treatment of severe asthma not responding to nebuliser therapy. In this life-threatening situation with severe airflow obstruction, monitoring of heart rate, PaO2, plasma potassium and the electrocardiogram should be mandatory and supplemental oxygen given so that serious adverse effects are presented.

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This paper aims to assess the efficacy and practical feasibility of implementing a ground source heat pump (GSHP) vis-à-vis an air source heat pump (ASHP) for domestic applications. The outcomes of this comparison are based on monitoring each of those systems installed in two near identical adjacent houses in Perth, Western Australia. The former house has an open-loop groundwater system. There is one family in each house whose operational requirements of the air conditioning system were independent. Data collected from both houses over 2 years was used to determine the cooling capacities delivered and coefficient of performance (COP), as a function of seasonal variations of ambient conditions. It was observed that the COP of the GSHP system was higher than that of the ASHP system for both heating and cooling. Further, these two performance parameters were independent of ambient conditions in the former whereas they show a perceivable ambient dependent trend in the latter.

Pasteurisation was investigated as a process to achieve high microbial quality standards in the recycling of water from unfiltered secondary effluents from a wastewater treatment plants in Melbourne, Australia. The relative heat sensitivity of key bacterial, viral, protozoan and helminth wastewater organisms (Escherichia coli, Enterococcus, FRNA bacteriophage, adenovirus, coxsackievirus, Cryptosporidium, and Ascaris) were determined by laboratory scale tests. The FRNA phage were found to be the most heat resistant, followed by enterococci and E. coli. Pilot scale challenge testing of a 2 ML/day pasteurisation pilot plant using unfiltered municipal wastewater and male specific coliphage (MS2) phage showed that temperatures between 69 °C and 75 °C achieved log reductions values between 0.9 ± 0.1 and 5.0 ± 0.5 respectively in the contact chamber. Fouling of the heat exchangers during operation using unfiltered secondary treated effluent was found to increase the energy consumption of the plant from 2.2 kWh/kL to 5.1 kWh/kL. The economic feasibility of pasteurisation for the current municipal application with high heat exchanger fouling potential can be expected to depend largely on the available waste heat from co-generation and on the efforts required to control fouling of the heat exchangers.