Despite rapid evolution in the area of microbial natural products chemistry, there is currently no open access database containing all microbially produced natural product structures. Lack of availability of these data is preventing the implementation of new technologies in natural products science. Specifically, development of new computational strategies for compound characterization and identification are being hampered by the lack of a comprehensive database of known compounds against which to compare experimental data. The creation of an open access, community-maintained database of microbial natural product structures would enable the development of new technologies in natural products discovery and improve the interoperability of existing natural products data resources. However, these data are spread unevenly throughout the historical scientific literature, including both journal articles and international patents. These documents have no standard format, are often not digitized as machine readable text, and are not publicly available. Further, none of these documents have associated structure files (e.g., MOL, InChI, or SMILES), instead containing images of structures. This makes extraction and formatting of relevant natural products data a formidable challenge. Using a combination of manual curation and automated data mining approaches we have created a database of microbial natural products (The Natural Products Atlas, ) that includes 24 594 compounds and contains referenced data for structure, compound names, source organisms, isolation references, total syntheses, and instances of structural reassignment. This database is accompanied by an interactive web portal that permits searching by structure, substructure, and physical properties. The Web site also provides mechanisms for visualizing natural products chemical space and dashboards for displaying author and discovery timeline data. These interactive tools offer a powerful knowledge base for natural products discovery with a central interface for structure and property-based searching and presents new viewpoints on structural diversity in natural products. The Natural Products Atlas has been developed under FAIR principles (Findable, Accessible, Interoperable, and Reusable) and is integrated with other emerging natural product databases, including the Minimum Information About a Biosynthetic Gene Cluster (MIBiG) repository, and the Global Natural Products Social Molecular Networking (GNPS) platform. It is designed as a community-supported resource to provide a central repository for known natural product structures from microorganisms and is the first comprehensive, open access resource of this type. It is expected that the Natural Products Atlas will enable the development of new natural products discovery modalities and accelerate the process of structural characterization for complex natural products libraries.

No abstract

Behavioral detection differs from appearance detection in that it identifies the actions performed by the malware rather than syntactic markers. Identifying these malicious actions and interpreting their final purpose is a complex reasoning process. This paper draws up a survey of the different reasoning techniques deployed among the behavioral detectors. These detectors have been classified according to a new taxonomy introduced inside the paper. Strongly inspired from the domain of program testing, this taxonomy divides the behavioral detectors into two main families: simulation-based and formal detectors. Inside these families, ramifications are then derived according to the data collection mechanisms, the data interpretation, the adopted model and its generation, and the decision support.

No abstract

Behavioural analysis for detection of malware has recently emerged as a new promising set of antiviral techniques: function-based detection is now considered along with sequence-based detection. Most of the antivirus publishers now claim to use behavioral analysis as a marketing argument. But the real impact of these "new" techniques seems to be mitigated since no real progress in the general antiviral fight has been noticed nowadays. This paper presents an evaluation methodology of the real capabilities of antivirus software with respect to the behavioral analysis. It is shown that contrary to the claims of some publishers, behavioural analysis is still very marginally used and implemented. These techniques are quite always either validated by or dependant on classical form-based detection methods (detection pattern as an example). In this context, we propose a generalised, theoretical detection model which considers at the same time both form-based and function-based detection and give some essential properties this model should exibhit to achieve a real behavioural-based detection.