AIM: The aim of the study is to create an easily reproducible experimental model of pancreonecrosis with the least aggressive technique of the operation. METHODS: Twenty-two outbred rabbits of comparable weight and age were included in the study. The animals were removed from the experiment 12, 24, and 48 h after the injection of auto-bile into the parenchyma of the pancreas. RESULTS: After completion of the experiment, rabbit pancreas was extracted, macroscopic and microscopic description was given. CONCLUSION: According to the results of the study, the proposed model is considered as consistent for reproducing pancreonecrosis in an experiment with less aggressive surgical technique.