No abstract

No abstract

Fast‐response smart hydrogels with combination of appropriate mechanical strength, self‐healing and tissue adhesiveness ability, and controllable drug release performance are highly desired as wound dressing practice. Herein, a novel dual‐crosslinking hydrogel with gold nanorods (AuNRs) well dispersed in its polymer network, D‐hydrogel@AuNR, was constructed via ultraviolet light initiated radical copolymerization of acrylamide (AM), isopropylacrylamide (NIPAAM), and dopamine methacrylamide (DMA) in a complex solution of AuNRs and cysteamine‐grafted oxidized sodium alginate (OSA‐SH). The produced D‐hydrogel@AuNR exhibits fast response to the near infrared light (NIR, 808 nm) exposure and a cumulative release level of encapsulated gentamicin sulfate (GS) up to 75% within 60 s laser irradiation. The dual‐crosslinking network that the first MBA crosslinked P(AM‐co‐NIPAAM‐co‐DMA) network and the second imine bonded network makes the tensile stress and tensile strain of D‐hydrogel@AuNR could reach up to 397.0 k Pa and 240%, respectively. Moreover, the received D‐hydrogel@AuNR also exhibits remarkable self‐healing ability and excellent cell affinity and tissue adhesiveness. These desirable properties of D‐hydrogel@AuNR together make it an appropriate candidate for practical wound dressing under different biomedical conditions.

A facile method that combines alkali-assisted oxidation and –SH chelation with a click chemistry reaction was employed to create an F-POSS polymer surface (fluorinated octavinyl polyhedral oligomeric silsesquioxane polymer)-based Cu mesh (F-POSS-OM).