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Lead and cadmium are most life threatening environmental pollutants nowadays due to increased industrialization. This study was carried out to study alteration in hematological and biochemical changes induced by lead and cadmium alone and in combination on rats. Forty two male albino Wistar rats were divided into 4 groups 12 rats in each group; group 1 (control) was given deionized water, group 2 (lead group) was given water with lead acetate @ 30 mg/kgb. wt, group 3 (cadmium group) was given water with cadmium chloride @15 mg/kgb. wt, group 4 (combined group) was given water with both lead acetate @ 30 mg/kgb. wt and cadmium chloride @15 mg/kgb. wt for 28 days. Hematobiochemical parameters were analyzed at 14 th day and 28 th day. Results showed a significant decrease in TEC, Hb and PCV where as TLC count was increased in toxic groups i.e group 2, 3 and 4 when compared to control. There was a significant elevated levels of biochemical parameters AST, ALT, ALP and decreased total protein indicating liver dysfunction. Increased levels of BUN and creatinine noticed in toxic groups indicated renal dysfunction. Anti-oxidant profile showed decreased GSH and increased TBARS in liver and kidney tissue in toxic groups indicating oxidant injury.