Histopathological and Ultrastructural Changes of Brain Induced by Lead and Cadmium Alone and Combined Exposure in Male Wistar Rats

Ramesh, Guguloth; Madhuri, D.; Lakshman, Mekala; Reddy, A. G.

doi:10.5455/ijlr.20190129020410

Cited by 3 publications

(4 citation statements)

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“…In this study, oral administration of CdCL 2 for three months induces degenerative changes of pancreatic acini with loss of normal lobular architecture, distorted pancreatic acini, degenerated and widely separated cells in the islets of Langerhans, dilated blood vessels and abundant perivascular cellular aggregates in pancreatic tissues stained with H&E. These lesions agreed with [22] who found congested vessels and interstitial infiltration of mononuclear cells, intra and inter lobular duct hyperplasia and mild loss of endocrine part of the pancreas in cadmium group of rats.…”

Section: Discussionsupporting

confidence: 84%

The Biochemical and Histological Effect of Cadmium Chloride on the Pancreas of Adult Albino Rats and the Possible Protective Effect of Nigella Sativa Seeds

Biram

Sekily

2020

Journal of Medical Histology

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Aim:The current study evaluates the important role of Nigella Sativa against cadmium (Cd) induced toxic changes in pancreas of rats. Materials and Methods: Eighteen adult Wistar albino rats were divided into three equal groups. Control group, cadmium treated group that received 5 mg CdCl 2 /kg BW/day dissolved in water orally for three months, and cadmium with Nigella sativa (NS) group received a mixture of 1g/kg/day of aqueous suspension of Nigella sativa seeds powder and 5 mg CdCl 2 /kg BW/day dissolved in water for three consecutive months. Hormonal assay of insulin was done. Pancreatic tissues were prepared for both Hematoxylin and Eosin and toluidine blue. Electron microscopic study of pancreatic tissues was also done.Results: The present study showed that the administration of CdCl 2 induced evident decrease in insulin serum level. The biochemical results were confirmed by histological investigations where degenerative changes of pancreatic acini with loss of normal lobular architecture, distorted pancreatic acini, degenerated and widely separated cells in the islets of Langerhans, blood vessels congestion and aggregation of perivascular cellular infiltrates were detected in pancreatic tissues stained with H&E. Toluidine blue-stained sections showed few deeply stained apical zymogen granules in some acini, whereas other acini showed absence of these granules. Administration of NS with CdCl 2 showed a significant improvement in the measured serum insulin level and histological pictures. Conclusion:CdCl 2 induced several toxic changes in the exocrine and endocrine parts of pancreas of rats. NS could protect the pancreas against these alterations.

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Section: Discussionsupporting

confidence: 84%

The Biochemical and Histological Effect of Cadmium Chloride on the Pancreas of Adult Albino Rats and the Possible Protective Effect of Nigella Sativa Seeds

Biram

Sekily

2020

Journal of Medical Histology

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“…The microscopic evaluation of bone marrow, together with haematological analysis, can provide a thorough understanding of the status of the haemtopoietic system. The observations recorded in the present study were in coordination with (Tham et al, 2013;Lu et al, 2014;Ramesh et al, 2018 andQi et al, 2019). Lead toxicity induces oxidative stress in variety cells throughout the body, including haematopoietic cells, by impairing the activity of enzymes such as glutathione peroxidase, catalase and superoxide dismutase (Tham et al, 2013).…”

Section: Histopathologysupporting

confidence: 86%

“…This results in free radicalinduced cell death ultimately, reducing cellularity in bone marrow, as observed in the present study. Further, accumulation of adipose tissue in bone marrow is another indication of reduced bone marrow density (Ramesh et al, 2018). These toxic changes were found to be ameliorated in the bone marrow of rats after the administration of curcumin along with lead acetate, attributed to the antioxidant and metal chelating properties of curcumin.…”

Section: Histopathologymentioning

confidence: 99%

Effect of Curcumin on Lead Induced Haematological, Oxidative and Bone Marrow Damage in Wistar Rats

Khare,

Dubey,

Verma

et al. 2024

IJAR

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Background: Lead is a well-recognized environmental pollutant and multisystemic toxin, which imposes a serious health concern in animals. Present study was conducted with the objectives to assess toxic effect of lead on mature and precursor blood cells and its amelioration with curcumin. Methods: Haematology and bone marrow cytology and histopathology were performed in rats for all the experimental groups after administration of lead acetate and curcumin in respective groups for 30 consecutive days. Result: Significant decrease in haemoglobin level, packed cell volume, erythrocytic, leukocytic and lymphocytic counts were observed in rats exposed to lead acetate on 15th and 30th day of experiment. Significant decrease in relative erythroid cell count and significantly increased myeloid to erythroid ratio were recorded in cytology along with histopathological alterations in bone marrow of lead exposed rats as compared to control rats. Oxidative stress marker malondialdehyde level was found to be significantly increased in association with significantly increased blood lead levels. Significant protection against these toxic changes was observed in rats administered with curcumin along with lead.

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“…Another study showed histopathological alteration in bone marrow of albino Wistar rats treated with 15 mg Cd/kg b.w. manifested as an increase in adipocytes in bone marrow and decrease in the cellular portion [88]. These changes were attributed to the direct action of Cd on the bone cells thereby decreasing bone formation and increasing bone resorption [88] [89].…”

Section: Cadmium-induced Tissue Injurymentioning

confidence: 99%

Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury

Das¹,

Al‐Naemi²

2019

ODEM

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Cadmium is a known environmental pollutant targeting various organs. Often implicated in cadmium toxicology is the formation of reactive oxygen species, overwhelming the free radical scavenging mechanisms and inducing oxidative stress. Acute cadmium intoxication has been shown to reduce antioxidant enzyme activity and induce oxidative stress. However, chronic intoxication has obscure outcomes in oxidative stress while the cell makes adjustments to overcome the toxicant load. Also linked with the occurrence of oxidative stress is inflammation. Stimulation of acute or chronic inflammation is mediated by different cascades. However, key events include activation of transcription factor, NF-κB and release of pro-inflammatory cytokines. Both oxidative stress and inflammation are implicated simultaneously in pathogenesis and induction of multi-organ tissue damage under cadmium exposure. This article reviews the impact of acute and chronic cadmium intoxication on inducing oxidative stress, inflammation and thereby inflicting tissue damage.

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Histopathological and Ultrastructural Changes of Brain Induced by Lead and Cadmium Alone and Combined Exposure in Male Wistar Rats

Cited by 3 publications

References 0 publications

The Biochemical and Histological Effect of Cadmium Chloride on the Pancreas of Adult Albino Rats and the Possible Protective Effect of Nigella Sativa Seeds

The Biochemical and Histological Effect of Cadmium Chloride on the Pancreas of Adult Albino Rats and the Possible Protective Effect of Nigella Sativa Seeds

Effect of Curcumin on Lead Induced Haematological, Oxidative and Bone Marrow Damage in Wistar Rats

Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury

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