Human herpes virus-8 (HHV-8) is linked to four lymphoproliferative diseases: primary effusion lymphoma, HHV-8 positive multicentric Castleman disease (MCD), HHV-8 positive diffuse large B cell lymphoma and HHV-8 positive germinotropic lymphoproliferative disorder (GLPD). The diagnosis of HHV-8 associated lymphoproliferative diseases is quite challenging because each entity is rare and has a wide morphological spectrum. Our aim is to emphasize the overlapping histopathological features of MCD and GLPD as well as to underline the importance of clinicopathological correlation in case these two entities cannot be distinguished by pathological examination.We present here a case of an 82-year-old male patient who was examined for weight loss and multiple lymphadenopathy. Histopathological examination of the axillary lymph node revealed lymphoid follicle structures of varying shapes and sizes, including some atrophic germinal centers. Plasmablast-like cells were notable in some of these areas. HHV-8 and Epstein Barr Virus (EBV) positivity were noted in some of these cells and in a small number of cells in the mantle zone. Based on these findings; a diagnosis of "HHV-8 and EBV positive lymphoproliferative disease" was established.Since HHV-8 positive MCD and GLPD have similar histopathological features, it may not be possible to distinguish these two entities by histopathological examination only. At this point, the importance of clinicopathological correlation becomes more evident, especially in the determination of the treatment protocol to be applied to the patient.

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METHODS Review of casesHodgkin Lymphoma diagnosed adult cases between 2013 and 2017, which chromogenic in situ ABSTRACT Purpose: Several studies suggest that the relation of Epstein-Barr virus (EBV) and Hodgkin lymphoma (HL). EBV and HL associations are reported at rates ranging from 20% to 100% that varies nationally and regionally. In this study; in the case of Hodgkin's lymphoma, the presence of EBV encoded RNA (EBER) by in situ hybridization method and it's distribution according to histopathological subtypes were investigated. Methods:We investigated the presence of EBV in Hodgkin Lymphoma diagnosed 107 adult cases between 2013 and 2017, which chromogenic in situ hybridization with EBV RNA probe has been in routine use were evaluated retrospectively with pathology reports.Results: There were 69 males and 38. Nodular Sclerosis Classical Hodgkin Lymphoma (NSCHL) was the most common (63 cases, 58,9%) followed by Mixed Cellularity Classical Hodgkin Lymphoma (MCCHL) (23 cases,21,5%). EBV was expressed in 40 cases (45,4%). High EBV association was found with NSCHL (50%) and MCCHL (48%). None of NLPHL was positive with EBER. Conclusion:In our series NSCHL is the most common histologic subtype and has higher percentages of EBV positivity as reported in developed countries. Our study has the largest series of patients investigating the relationship between HL and EBER in our country. For further comments more studies, particularly from Turkey, are needed to determine the actual epidemiological pattern of HL in the region and to define the role of EBV in HL.

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