The study aimed at investigating morphofunctional and hematological features of the first-year students’ health condition. The health status for a total of 400 first-year students, who arrived for studying from the northern region (North Kazakhstan) and the southern region (Turkestan, Kyzylorda), was estimated during the study. The morphological (BMI, vital lung capacity, etc.) and hematological (the total number of red blood cells, white blood cells, the concentration of hemoglobin in the blood, etc.) indicators of the health status were investigated. By comparing the condition of physical health in students from both regions, a significant difference in main morphofunctional and hematological indices has been established. The functional indicators of the cardiovascular and respiratory systems were higher in students from the southern region, which reflects a good adaptive reaction to studying at a university, as well as new climatic and geographical conditions. Students from the southern region were reported to have lower red blood cell amounts and diagnosed with mild anemia compared to those from the northern region. Therefore, constant monitoring of the health condition among youth is required to develop effective tactics for the students’ smooth adjusting to living in new climatic conditions.