Dentigerous cyst is the most common odontogenic cyst of the jaws after radicular cyst and is usually observed as unilateral involvement. The multiple involvement of this cyst is rather rare if not accompanied of an underlying systemic disease or syndrome. In this report, radiographic findings and surgical treatment of a patient with non-syndromic multiple dentigerous cyst, who applied to the clinic for prosthetic treatment were presented. Panoramic radiograph revealed radiolucencies associated with the crowns of bilateral mandibular third molar teeth, right maxillary third molar, bilateral maxillary canines. In cone-beam computed tomography (CBCT), it was revealed as well-defined unilocular radiolucent areas surrounded by sclerotic border and related to the crown of the unerupted teeth. In intermittent sessions, multiple dentigerous cysts were enucleated and the associated impacted teeth were extracted under local anesthesia. According to the comprehensive research, this is the first case-report presenting the surgical treatment and revealing the radiographic findings in elderly non-syndromic patient with multiple dentigerous cyst in maxilla and mandible.