Background: Dental caries is a multifactorial illness caused by bacteria. Lactobacillus acidophilus is one of the bacteria causing caries, where it continues the caries process. That is why the antibacterial agent is needed. A cherry (Muntingia calabura) is fruit having many benefits for health, which one of them is as an antibacterial agent. It contains flavonoid, tannin, alkaloid, and terpenoid, which can function as the antibacterial agent.  Aim :The study aimed to determine the influence of cherry (Muntingia Calabura) extract in preventing the growth of L.acidophilus. Method: True experimental laboratory with a post-test only control group design and 24 samples. Cherries were extracted by using maceration. Then, the phytochemical test was conducted to discover antibacterial substances. The antibacterial test was done by using the dilution method to know Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Results: Minimum Inhibitory Concentration (MIC) could not be seen, and Minimum Bactericidal Concentration (MBC) showed that all concentration 6,25%, 12,5%, 25%, and 50% and positive control were able to kill a bacterium L. acidophilus. Conclusions: There is an influence of cherry extract on the grow

Wound care by using wound dressing has been evolved available in various physical forms including hydrogels with the highest global use reaching 43%. Nowadays, hydrogels are available at high cost because produced from synthetic materials, so natural materials are needed to obtain antibacterial wound dressing. This study aims to analyze the hydrogel patch PVA/chitosan/starch infused liquid smoke and vitamin K collard greens extract which are antibacterial effects and accelerates wound healing. This study was a laboratory experiment. Collard greens were extracted by using the Direct Solvent Extraction II method. The membrane characteristic tested using SEM test. The parallel streak method (AATCC 147-2004) was used for antibacterial testing. The hydrogel patch application was carried out on 28 male Rattus norvegicus strain wistar rats. They were given incisions wound and treated by a control group and 3 treatment groups and conducted wound healing analysis on the 4th,7th,11th and 14th day observation. The antibacterial test showed the hydrogel patch infused liquid smoke with a concentration of 12% was the optimum concentration inhibiting S. aureus. In conclusion, the hydrogel patch has a smooth and porous surface, can be inhibited the growth of S. aureus, and proven to completely heal the animal wound.

Ulserasi mukosa mulut sering terjadi biasanya berupa bercak putih kekuningan dengan permukaan agak cekung dan tepi kemerahan, serta disertai rasa sakit. Berdasarkan penelitian yang sebelumnya kunyit memiliki zat anti inflamasi yang dapat membantu mempercepat proses penyembuhan ulserasi. Penelitian ini bertujuan untuk mengetahui efektivitas kunyit (curcuma domestica) terhadap ulserasi mukosa mulut Rattus Norvegicus secara in vivo. Jenis penelitian ini adalah penelitian eksperimental semu dengan rancangan the post test- only control group design dengan hewan coba Rattus Norvegicus. Dalam penelitian ini terdapat 2 kelompok perlakuan, yaitu satu kelompok kontrol negatif, satu kelompok perlakuan dengan ekstrak kunyit. Pengambilan data berdasarkan pengamatan histopatologi dan klinis terhadap peningkatan jumlah makrofag dan pengukuran diameter ulkus. Hasil penelitian berdasarkan uji perbandingan antara kedua kelompok dengan uji Independen T-test menunjukkan bahwa jumlah makofag dari hari ke 1 sampai hari ke 3, 7, 10 terdapat perbedaan yang bermakna antara kelompok perlakuan dan kelompok kontrol negatif yaitu p<0,05 dan perbandingan pengukuran diameter dari hari ke 1, 3, 7, 10 tidak terdapat perbedaan yang bermakna anatara kelompok perlakuan dan kelompok kontrol negatif p>0,05. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahawa ekstrak kunyit (curcuma domestica) berpengaruh terhadap penyembuhan ulserasi mukosa mulut dilihat berdasarkan peningkatan jumlah makrofag dan pengecilan diameter ulserasi.