Long noncoding RNAs (lncRNAs) have increasingly been shown to be important biological regulators involved in numerous diseases. Further, increasing evidence demonstrates that circulating lncRNAs can be used as diagnostic biomarkers. Therefore, the purpose of this study was to evaluate the potential for circulating lncRNAs as novel biomarkers for the diagnosis of preeclampsia. In the present study, we measured the expression of five lncRNAs known to be relevant to the uterus in whole blood samples from 48 preeclampsia patients and 24 non-preeclampsia healthy subjects using qRT-PCR. We found that circulating levels of lncRNA BC030099 were significantly higher in patients with preeclampsia (1.232 ± 0.4870) than in non-preeclampsia healthy subjects (0.9928 ± 0.2008, p < 0.05). The area under the receiver operating characteristic (ROC) curve for lncRNA BC030099 was 0.713. Univariate and multivariate analyses identified lncRNA BC030099 as an independent predictor for preeclampsia. In brief, our results suggest that increased plasma levels of lncRNA BC030099 are associated with an increased risk of preeclampsia and may be considered a novel biomarker.

Objective To map the current research status and understand existing findings regarding end-of-life care needs in Mainland China. Method First-hand, empirical studies on the needs of dying patients and/or their families in Mainland China were searched in Web of Science, Scopus, Proquest, Taylor & Francis Online and CNKI in December 2019. Findings were synthesized. Results A total of 33 (10 qualitative) studies were involved. Chinese dying patients and their families had physical, psychological, social, and spiritual needs and needs for knowledge and information. Prevalent needs of dying patients were mainly symptom control and decent look, being treated kindly by professional caregivers, family accompany, dignity, and comfortable environment. Families mainly need healthcare professionals to take good care of patients and wishes for information, knowledge, and facilities to help themselves become better caregivers. Conclusions Findings lay the foundation for effective and tailored services for Chinese clients and provided insights for future investigations.

Objective This study aims to systematically examine Chinese cancer patients' and families' preferences for information disclosure to the patient, patient awareness, and predictors of patient awareness. Methods The Preferred Reporting Items for Systematic reviews and Meta‐Analyses guidelines were followed. Web of Science, Scopus, Proquest, Taylor & Francis Online, and China National Knowledge Infrastructure were searched in April 2022 and Chinese Biomedical Literature Database in July 2022 for quantitative studies. The Mixed Methods Appraisal Tool was used for quality assessment. Results A total of 22 studies were included, and the average quality score was 0.65/1. Meta‐analyses showed that 89.6% and 81.8% of cancer patients wanted to know their diagnosis and prognosis, respectively. Meanwhile, 50.0% and 32.4% of families prefer diagnosis disclosure and prognosis disclosure to the patient, respectively. Significantly more patients than families favored disclosure to the patient. In reality, only 59.3% of cancer patients know their diagnosis, and 19.9% know their prognosis. For predictors, while patients' gender, cancer type (breast cancer or not), treatment method (operation or other), or complications (yes or no) do not influence diagnosis awareness, being younger, being married, having higher educational attainment, having early‐stage rather than late‐stage cancer, and being in a higher‐grade hospital all predict better chances of knowing a diagnosis. No study explored predictors of patients' prognosis awareness. The findings did not vary according to publication time or sample size. Conclusions Chinese cancer patients are eager to know their diagnosis and prognosis, but families are hesitant about disclosure to the patient, and patients' awareness is low. While cultural, legal, and medical backgrounds lay the foundation for information disclosure in Mainland China, case‐by‐case practical factors also make a difference.

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LANGUAGE NOTE | Document text in Chinese; abstract also in English.本文首先對中國傳統醫學生活的結構和運動模式兩個方面進行了探討，借此提出以下觀點：中國傳統的醫患倫理關係並不是一種典型的職業倫理關係，它建立在中國傳統醫學學術和社會生活的基礎之上，其道德效力整合於這種特定的生活境遇之中；醫生與病人都被整合在社會倫理關係的網路之中，醫患關係根據醫病雙方各自具體的社會倫理身份以及具體的醫療活動場景的不同而運動變化。這樣一種倫理關係使中國傳統醫學生活充滿了矛盾：醫家雖然將醫學稱為“奪造化之權，以救人生死”《醫學源流論˙醫非人人可學論》的大“道”，但又必須承認其在現實性上是一種“持方技以事上”的小“術”，苦苦掙扎在崇高的道德責任感和低下的自我倫理認知之間；病家既保有一種有限的選擇和評價醫生、干預診療活動的自主權，又必須遵循社會倫理法則來認識和調整與醫生的關係，在和醫生的相互角力中維護自己的權益。傳統醫學道德過於追求高尚而遠離普通醫生的生活實際，這就大大消弱了它對現實生活的指導力量，無助於建立一種合理的職業倫理規範，更違背了中國傳統倫理學“德得相通”的最高道德原則。Using examples from ancient texts, this paper contends that the traditional physician-patient relationship should be understood and interpreted within the matrix of the social and ethical network of a society. As such, the physician-patient relationship is not what we call “a professional relationship,” in that there is no fixed or objective standard to qualify it. In the Confucian tradition, for instance, the physician-patient relationship changes according to the social identity of the patient. The moral responsibility of the physician also becomes ambiguous when he or she is required to treat the patient as a “relative” or “friend.” The patient, in contrast, has a very limited “autonomy,” if there is such a thing, to choose his or her own doctors and make medical decisions. The same situation can be seen in Daoist medical practice when the physician has to struggle between the “Dao of medicine” and the “skill of medicine,” or between the moral dimension of medicine and the efficaciousness of medicine. The medical profession in the past was never an independent entity with independent ethical standards, and has always been part of a wider value system.Because of this, when medical professionals nowadays try to adopt Western ideas underpinned by different principles and theories, they find moral clashes between two traditions due to their conflicting value systems. As a result, concepts such as “patient rights” are at odds with the traditional understanding of the physician-patient relationship, which emphasizes context and situation. This paper also criticizes virtue-based morality in China, contending that principle-based morality would be better for reconstructing a more objective standard of morality for medical professionals in China.DOWNLOAD HISTORY | This article has been downloaded 207 times in Digital Commons before migrating into this platform.